HIV中和抗体在抗HIV感染中的作用  

Roles of HIV neutralizing antibodies in the control of HIV infection

作　　者：刘沐桑[1] 郑楠[2] 刘维达[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042 [2]南京大学医学院

出　　处：《国际皮肤性病学杂志》2011年第1期52-54,共3页International Journal of Dermatology and Venereology

摘　　要：HIV的中和抗体可以与HIV病毒特异结合并且阻断病毒侵入细胞的抗体。HIV中和抗体的靶位是病毒的膜蛋白上那些与细胞受体结合和膜融合有关的区域，抗体的结合与相关蛋白的构象紧密相关，目前的相关研究为抗HIV药物和杀微生物剂的研制提供了理论基础。HIV具有逃逸中和抗体的能力。因此，为设计有效的疫苗，需要对抗原进行理性设计，以便更有效的诱导广谱中和抗体。概述HIV的侵入机制，中和抗体与侵入关键蛋白、靶点以及抗HIV疫苗研究的关系和进展。Neutralizing antibodies specific for HIV can bind to the virus and inhibit HIV entry into host cells. The targets of HIV-specific neutralizing antibodies are the sites associated with receptor binding or membrane fusion on the envelop proteins of HIV. Relevant studies have provided theoretical basis for developing anti-HIV medicines and microbicides. The neutralization is sensitive to the conformation of related proteins. On the other hand, HIV has a latent ability to escape from antibodies neutralization. Therefore, the rational design of antiget, to induce broad-spectrum neutralizing antibodies is necessary for the development of successful vaccines. This paper introduces HIV invasion mechanism as well as the relationship of HIV neutralizing antibodies with entry-related crucial proteins, targets and anti-HIV vaccines.

关 键 词：HIV 感染 中和抗体 

分 类 号：R392[医药卫生—免疫学]