复合海绵及载药复合海绵止血性能研究  

Hemostatic efficacy of the complex sponge and drug-loaded complex sponge

作　　者：李东红[1] 刁俊林[1] 刘建仓[1] 胥婷[1] 

机构地区：[1]第三军医大学附属大坪医院野战外科研究所第二研究室,创伤、烧伤与复合伤国家重点实验室,重庆400042

出　　处：《中华创伤杂志》2011年第1期64-67,共4页Chinese Journal of Trauma

基　　金：军队“十一五”课题资助项目（06MA201）;创伤、烧伤与复合伤国家重点实验室资助项目（SKLZZ200812）;志谢 感谢刨伤、烧伤与复合伤国家重点实验室对本课题提供的部分资金资助.

摘　　要：目的 评价复合海绵及其载药后对兔肝、脾创面的局部止血性能.方法 采用复合交联、冷冻干燥得到复合海绵;将其浸入一定浓度的氨甲环酸中,冻干得载药复合海绵.在兔肝、脾损伤创面,分别敷用复合海绵和载药复合海绵,观察正常情况下和肝素抗凝后兔肝、脾创面的出血时间及出血量,并与可吸收性明胶海绵和壳聚糖海绵比较.结果 正常情况下,复合海绵的止血时间和出血量较明胶海绵组和壳聚糖海绵组缩短或减少（P＜0.05,0.01）;在肝素抗凝后,明胶海绵止血时间明显延长,而壳聚糖海绵和复合海绵的变化并不明显.载药复合海绵与复合海绵相比,在正常状态下止血性能有明显提高,但在凝血功能障碍时止血性能没有显著变化,且止血性能与载药量不呈线性关系.结论 复合海绵和载氨甲环酸复合海绵较明胶海绵止血性能明显提高,尤其是在凝血功能障碍时.Objective To evaluate the hemostatic efficacy of complex sponge and drug-loaded complex sponge on hepatic and splenic wounds in rabbits. Methods Complex sponge was prepared by means of cross-linking and lyophilization. Then, the sponge was immersed into the tranexamic acid solution and lyophilized to obtain the drug-loaded sponge. The complex sponge and drug-loaded complex sponge were respectively used on the hepatic and splenic wounds of rabbits to observe the bleeding time and blood loss under normal and liquemine anticoagulation respectively. The gelatin sponge and the chitosan sponge were used as controls. Results Under normal condition, the hemostatic time and blood loss of the complex sponge was decreased obviously compared with the gelatin sponge （ P〈 0. 01 ） and compared with the chitosan sponge （ P 〈 0. 05 ）. Posterior to liquemine anticoagulation, the hemostatic time was increased obviously in the gelatin sponge but showed no difference for the chitosan sponge and the complex sponge. Compared with complex sponge, the hemostatic efficacy of the tranexamic acid-loaded complex sponge was improved markedly for normal rabbits. While the hemostatic efficacy showed no significant change for rabbits with coagulation disorders, when there was no linear relationship between the hemostatic efficacy and the content of tranexamic acid. Conclusions The hemostatic efficacy of the complex sponge and the drug-loaded complex sponge surpass obviously that of the gelatin sponge, especially for the rabbits with coagulation disorders.

关 键 词：止血 复合海绵 氨甲环酸 

分 类 号：R9[医药卫生—药学]