辨体施膳方药对衰老模型小鼠的影响  

Effects of Chinese medicine formula with the distinguished body catered facilities to aging-model mice

作　　者：沈明勤[1] 王志刚[1] 罗宇慧[1] 石磊[1] 王小宁[1] 

机构地区：[1]江苏省中医药研究院,江苏南京210028

出　　处：《中国老年学杂志》2011年第1期45-47,共3页Chinese Journal of Gerontology

基　　金：国家"十一五"科技支撑计划资助项目(2006BAI13B04)

摘　　要：目的观察气虚综合方一、二对衰老模型小鼠的抗衰老作用。方法小鼠皮下注射D-半乳糖125 mg.kg-1.d-1连续30 d制成衰老模型,同时灌胃给予气虚综合方一〔22.0、5.5 g（生药）/kg〕、方二〔18.3、4.6 g（生药）/kg〕的提取物30 d,观测对模型小鼠耐力（游泳时间）、免疫器官（胸腺、脾）系数、血清SOD,MDA,GSH-Px水平及脑组织脂褐素（LPF）水平的影响。结果气虚综合方一、二给药后均能提高衰老模型小鼠的耐力,延长模型小鼠的游泳时间（P〈0.01）,抑制免疫器官脾脏的萎缩（P〈0.05）,提高衰老模型小鼠的血清SOD、GSH-Px活力（P〈0.05~0.01）,降低其血清MDA的含量（P〈0.05~0.01）和脑组织中LPF的含量（P〈0.05~0.01）。结论气虚综合方一、二给药后均有一定的抗衰老作用,其中方一的作用明显。Objective To observe the anti-aging effects of Chinese medicine formula Ⅰand Ⅱon aging-model mice.Methods The aging-model was made by hypodermic injection the D-galactose 125 mg·kg-1·d-1 in mice with 30 days. And the extracts from Chinese medicine formula Ⅰ（22 and 5.5 g/kg） and Ⅱ（18.3 and 4.6 g/kg） were intragastric（i.g） in model mice simultaneously.The endurance capacity （swimming time）,index of immunity organs（thoracic gland and spleen）,the serum levels of SOD,MDA,GSH-Px and the LPF in brain tissue were detected eventually.Results The endurance capacity of model mice was elevated markedly.The swimming time of mice was prolonged.The tendency of atrophy in spleen was inhibitive.The vital forces of SOD and GSH-Px in serum were raised.The serum level of MDA in mice was decreased.So did the LPF in brain tissue.Conclusions The Chinese medicine formula Ⅰand Ⅱboth have the anti-aging effects on aging-model mice. But the Formula Ⅰis better than FormulaⅡ slightly.

关 键 词：辨体施膳 抗衰老 抗氧化 

分 类 号：R21[医药卫生—中医学]