艾灸对血管性痴呆患者症状及脑脊液中神经肽类物质水平的影响  

Impacts of moxibustion on vascular dementia and neuropeptide substance content in cerebral spinal fluid

作　　者：陈浩[1] 王频[1] 杨骏[2] 柳刚[2] 

机构地区：[1]安徽中医学院针灸骨伤临床学院,合肥230038 [2]安徽中医学院附属针灸医院

出　　处：《中国针灸》2011年第1期19-22,共4页Chinese Acupuncture & Moxibustion

基　　金：安徽省自然科学基金项目:30430070

摘　　要：目的:观察艾灸疗法在改善血管性痴呆(VD)患者临床症状和神经肽物质方面的作用,探讨艾灸治疗VD的部分机制。方法:87例VD患者随机分成艾灸组(43例)和西药组(44例)。艾灸组隔附子片灸百会,悬灸神庭、大椎;西药组口服吡拉西坦素片,经4个疗程治疗后,比较治疗前后智能检查量表(HDS)、智能改变量表(MMSE)及日常生活能力量表(ADL)评分变化,与学习记忆相关脑脊液中的活性物质生长抑素(SS)、精氨酸加压素(AVP)水平。结果:艾灸组总有效率为81.4%(35/43),优于西药组的63.6%(28/44)(P<0.01)。两组治疗前后HDS、MMSE与ADL量表评分较治疗前均改善(P<0.05,P<0.01),艾灸组MMSE、ADL量表评分改善优于西药组(均P<0.05)。两组治疗后脑脊液SS、AVP水平较治疗前明显升高(均P<0.01),艾灸组治疗后SS、AVP水平与西药组比较明显改善(P<0.05,P<0.01)。结论:艾灸无论在改善临床症状积分还是在调控与学习记忆相关的神经肽物质方面均优于口服吡拉西坦素片,值得推广应用。Objective To observe the effects of moxibustion therapy on the improvements of clinical symptom scale score and neuropeptide substance in vascular dementia （VD） and investigate a part of mechanism of moxibustion on Vd. Methods Eighty-seven cases of VD were divided randomly into a moxibustion group （43 cases） and a western medicine group （44 cases）. In moxibustion group, the isolated moxibustion with Typhonium Rhizome was applied to Baihui （BL 20）, and suspended moxibustion was used on Shenting （BL 24） and Dazhui （GV 14）. In western medicine group, Piracetam tablet was taken orally. After 4-session treatment, the scores in Hasegawa＇s Dementia Scale （HDS）, Mini Mental Status Examination （MMSE） and Activity of Daily Living Scale （ADL） as well as the content of active substances, somatostatin （SS） and arginine vasopressin （AVP） in cerebral spinal fluid relevant with learning and memory were compared with those before treatment. Results The total effective rate was 81.4% （35/43） in moxibustion group, which was superior to 63.6% （28/44） in western medicine group （P〈0.01）. The scores in HDS, MMSE and ADL after treatment were all improved as compared with those before treatment in two groups （P〈0.05, P〈0.01）. The improvements of the scores in MMSE and ADL in moxibustion group were superior to those in western medicine group （both P〈0.05）. After treatment, SS and AVP content in cerebral spinal fluid increased remarkably as compared with those before treatment in two groups （all P〈0.01）, and SS and AVP levels after treatment in moxibustion group were improved significantly as compared with those in western medicine group （P〈0.05, P〈0.01）. Conclusion Moxibustion therapy is superior to oral administration of western medicine no matter in the improvement of symptom scores or in the regulation of neuropeptide substances relevant with learning and memory, which deserves to be promoted in application

关 键 词：血管性痴呆 艾灸 生长抑素 精氨酸加压素 

分 类 号：R246.6[医药卫生—针灸推拿学]