利用难溶性药物渗透泵处方设计专家系统设计法莫替丁双层渗透泵控释片  

Design push-pull osmotic pump tablets of famotidine based on an expert system for the formulation design of osmotic pump of poor water-soluble drug

作　　者：张志宏[1,2] 金杰[1] 张宏武[2] 辛伟[2] 贾国宾[3] 吴文芳[2] 潘卫三[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]石药集团中奇制药技术(石家庄)有限公司,河北石家庄050051 [3]河北远征药业有限公司,河北石家庄050051

出　　处：《药学学报》2011年第1期109-114,共6页Acta Pharmaceutica Sinica

摘　　要：本文目的在于利用本课题组建立的难溶性药物渗透泵处方设计专家系统设计法莫替丁双层渗透泵控释片。首先通过文献检索和实验测定获得系统所需要的参数;然后将各参数输入系统并运行程序,此时系统会给出设计结果;最后根据系统设计结果制备样品并检测法莫替丁双层渗透泵控释系统体外释药情况。结果发现经过很短的周期便获得了释放24 h的法莫替丁控释片,同时也验证了专家系统的实用性。The purpose of this study is to design push-pull osmotic pump（PPOP） tablets of famotidine using the expert system for the formulation design of osmotic pump of poor water-soluble drug which had been established by the authors.Firstly,the parameters which were requisite of the system input were obtained from literatures and experimental tests.Then the parameters were input into the system,and the program was run.The system displayed the designed formulations sequential.Finally,famotidine PPOP was prepared according to the designed formulations and the in vitro dissolution was carried out.It was found out that the target formulation of famotidine PPOP which could release for 24 hours was obtained in a very short period.Meanwhile,the practicability of the established expert system was proved.

关 键 词：渗透泵 专家系统 法莫替丁 难溶性药物 处方设计 

分 类 号：R943[医药卫生—药剂学]