胆道闭锁患儿Kasai术后早期胆管炎相关危险因素分析  

Risk factors of the early cholangitis after Kasai operation for biliary atresia in children

作　　者：黄磊[1] 司新敏[2] 冯杰雄[3] 易军[1] 

机构地区：[1]南京医科大学附属南京儿童医院小儿外科,210008 [2]南京医科大学附属第一医院消化内科 [3]华中科技大学同济医学院附属同济医院小儿外科

出　　处：《中华小儿外科杂志》2011年第1期17-20,共4页Chinese Journal of Pediatric Surgery

基　　金：国家青年科学基金资助（编号：30901571）

摘　　要：目的 探讨影响胆道闭锁患儿（biliary atresia,BA）经典Kasai术后早期胆管炎发生的相关因素.方法 对本组中35例BA患儿的临床资料应用二项分类logistic同归分析方法作回顾性分析.结果 胆道闭锁患儿术后近期胆管炎发生与术后胆汁引流效果、术后辅以激素治疗及术中预留胆支长度有显著相关性,而与患儿性别、手术日龄、术前总胆红素及肝功能、手术前后辅以熊去氧胆酸和苯巴比妥利胆退黄治疗、术中设置防反流瓣及术后抗感染力度等因素无关.结论 胆道闭锁患儿Kasai术后胆汁引流效果好,辅以激素治疗,同时术中预留胆支长度充分的BA患儿,其术后不易发生早期胆管炎;反之,患儿发生早期胆管炎风险增加.Objective To evaluate the factors affecting the early post-operative cholangeitis after classical Kasai operation for biliary atresia （BA） in children. Methods The clinical data of thirty-five BA children from pediatric surgery department of Nanjing Childrens Hospital was retrospectively analyzed using binary logistic regression analysis. Results The occurrence of early cholangitis after classical Kasai operation was found to correlate with post-op biliary drainage effect, hormone therapy and the length of Roux-loop in operation. No correlation could be established between early cholangeitis and sex,age, total bilirubin and pre-op liver function, ursodeoxycholic and luminal therapy, the installation of anti-refluxing valve in operation and the dosage of antibiotics. Conclusions Good biliary drainage,hormone therapy and sufficient length of Roux-loop were associated with decreased risk of early cholangitis.

关 键 词：胆道闭锁 胆管炎 危险因素 

分 类 号：R726.5[医药卫生—儿科]