天津地区汉族人群炎症细胞因子基因多态性与冠脉支架术后再狭窄的关系  

Relationship between Inflammatory Cytokines Gene Polymorphism and Restenosis after Percutaneous Coronary Intervention in Tianjin Population

作　　者：高静[1,2] 崔让庄[2] 刘寅[3] 毛用敏[2] 周津[3] 刘婷[2] 陈倩[2] 赵福梅[2] 杨桂铭[2] 

机构地区：[1]天津医科大学,300070 [2]天津市胸科医院心血管病研究所 [3]天津市胸科医院心内科

出　　处：《天津医药》2011年第1期27-30,98,共5页Tianjin Medical Journal

基　　金：天津市卫生局课题资助项目(项目编号:05KYZ90)

摘　　要：目的:探讨天津地区汉族人群白细胞介素(IL)-6-572C/G、IL-1β-511C/T及IL-10-592C/A的基因多态性及其对经皮冠状动脉介入治疗(PCI)术后再狭窄的影响。方法:437例接受PCI并进行冠脉造影随访的患者,按冠脉造影结果分为再狭窄组(166例)和非再狭窄组(271例),用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测IL-6启动子(-572)、IL-1β启动子(-511)及IL-10启动子(-592)位点基因型和等位基因频率的分布。结果:(1)2组IL-6-572C/G、IL-1β-511C/T及IL-10-592C/A基因型和等位基因频率间差异无统计学意义(均P>0.05)。(2)多因素Logistic回归分析显示脂蛋白a、急性冠状动脉综合征(ACS)、术前狭窄程度、靶病变长度为支架内再狭窄(ISR)的可能危险因素(均P<0.05),参照血管直径、支架直径为ISR的可能保护因素(均P<0.05)。结论:IL-6-572C/G、IL-1β-511C/T及IL-10-592C/A基因多态性与天津地区汉族人群再狭窄的发病无关。Objective：To investigate the relationship of inflammatory cytokines gene polymorphism with restenosis after percutaneous coronary intervention （PCI） in Tianjin Chinese-Han population. Methods：Four hundred and thirty-seven patients who successfully underwent PCI with a follow-up angiography were divided into the restenosis group （n = 166） and non-restenosis group （n = 271）. The frequencies of IL-6 polymorphism （-572C/G）, IL-1β polymorphism （-511C/T） and IL-10 polymorphism （-592C/A） in promoter region were genotyped respectively by restricted fragment length polymorphism using polymerase chain reaction （PCR-RFLP） method. Results：（1） There were no significant differences in frequencies of IL-6-572, IL-1β-511 and IL-10-592 genotype and allele between 2 groups （P 0.05）. （2） Logistic regression analysis revealed a positive correlation between lipoprotein （Lp）a, acute coronary syndrome （ACS）, preoperative stenosis, length of target lesion stenosis and restenosis （P 0.05, respectively）; and there was a negative correlations between the stent diameter, the diameter of reference vessel before stent implantation and restenosis（P 0.05, respectively）. Conclusion：There was no association between polymorphism of IL-6 -572 C/G, IL-1β-511 C/T and IL-10 -592 C/A gene and restenosis after PCI in the Tianjin Chinese-Han population.

关 键 词：血管成形术 经腔 经皮冠状动脉 冠状动脉再狭窄 白细胞介素类 冠状血管造影术 基因频率多态性 限制性片段长度 Logistic模型 

分 类 号：R699.2[医药卫生—泌尿科学]