纳米羟基磷灰石/聚酰胺在脊髓型颈椎病椎体次全切减压融合术中的应用  

Application of n-HA/PA66 in anterior cervical subtotal corpectomy and fusion for treatment of cervical spondylotic myelopathy

作　　者：杨朝垒[1] 王利民[1] 谭洪宇[1] 王卫东[1] 廖文胜[1] 鲍恒[1] 刘屹林[1] 

机构地区：[1]郑州大学第一附属医院骨科,郑州450052

出　　处：《复旦学报（医学版）》2011年第1期14-17,共4页Fudan University Journal of Medical Sciences

基　　金：国家科技支撑计划课题(2007BAE13B00)

摘　　要：目的探讨纳米羟基磷灰石/聚酰胺（n-HA/PA66）在脊髓型颈椎病椎体次全切减压融合术中的应用效果。方法对30例脊髓型颈椎病患者均行颈椎前路椎体次全切n-HA/PA66植入钛板内固定术,对其疗效及融合情况进行评价。结果 30例患者均成功完成手术并获得随访,随访时间9~17个月,平均12.6个月。所有患者神经症状均明显改善,植入物未引起过敏及毒性反应,颈椎生理曲度、椎间高度有良好的恢复和维持,术后6~8个月时获得植骨融合,n-HA/PA66人工椎体后缘存在不同程度的异位骨化。结论 n-HA/PA66人工椎体作为颈椎前路手术植骨材料融合率高,可以有效保持颈椎生理曲度及椎间高度。长期效果有待进一步观察。Objective To discuss the application effect of nano-hydroxyapatite and polyamide composite（n-HA/PA66） in anterior cervical subtotal corpectomy and fusion with plate for the treatment of cervical spondylotic myelopathy. Methods Thirty patients with cervical spondylotic myelopathy were treated with anterior cervical subtotal corpectomy,in which n-HA/PA66 was grafted and platted for the decompression and fusion.The clinical results and graft fusion were evaluated after the operation. Results All patients were operated successfully and followed up for 9 to 17 months with an average of 12.6 months.The neurological symptoms and signs of patients were greatly improved.There was no allergic and toxic reactions induced by n-HA/PA66 implantation.Imaging studies showed that cervical alignments and intervertebral height were well maintained,and graft fusions were achieved in all cases 6 to 8 months after operation.However,there were heterotopic ossifications of different degrees in the posterior edge of n-HA/PA66 artificial vertebral body. Conclusions n-HA/PA66 artificial vertebral body has good fusion rate,and could effectively maintain the biological alignment and cervical intervertebral height.The long-term effects depend on further follow-up.

关 键 词：颈椎病 羟基磷灰石 聚酰胺 椎体次全切除 植骨融合 

分 类 号：R687.3[医药卫生—骨科学]