健康成年人手部主动及被动运动时大脑功能区的功能性磁共振成像研究  

Functional magnetic resonance imaging of active and passive hand movement

作　　者：蔡伟森[1] 吴毅[1] 吴军发[1] 朱王连 赵小虎[2] 范明霞[3] 李建奇[3] 胡永善[1] 

机构地区：[1]复旦大学附属华山医院康复医学科 复旦大学医学神经生物学国家重点实验室,上海200040 [2]同济大学附属同济医院放射科 [3]上海市磁共振重点实验室 华东师范大学物理系

出　　处：《中华物理医学与康复杂志》2011年第1期20-24,共5页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：基金项目：国家高新技术计划（863计划）资助项目（2007AA022482）,上海市闸北区卫生局资助项目（2006重点05）,华山医院科研启动基金项目（院237）

摘　　要：目的 利用血氧水平依赖性功能性磁共振成像技术探讨健康成年人手部主动、被动对掌运动时的脑激活区的特点,为运动疗法治疗脑卒中提供理论依据.方法 9名健康成年人参加实验.以右手主动及被动对掌运动作为刺激模式,采用区块设计,利用SPM5软件进行数据处理.测量位于对侧感觉运动区及运动前区的脑激活区的中点,并统计各脑区出现激活的频数.结果 主动及被动手对掌运动时主要激活的脑区包括：对侧感觉运动皮质（SMC）区、对侧运动前皮质（PMC）区、双侧辅助运动区（SMA）及同侧小脑,其中对侧SMC区的激活频率最高;被动运动时所激活的对侧SMC和PMC区的几何中心较主动运动时偏后.结论 主动和被动对掌运动均可引起运动相关脑区激活,两种运动模式所激活脑区在分布上无明显差别,但被动运动所激活的对侧SMC和PMC区几何中心较主动运动偏后.Objective To assess differences in brain activation between active and passive movement of the right hand using blood oxygen level-dependent functional magnetic resonance imaging （BOLD-fMRI）. Methods Nine healthy adult right handed volunteers were studied. fMRI was performed with active and passive finger-to-finger movement. Results Right hand active and passive movement produced significant activation in the contralateral sensorimotor cortex （ SMC ）, the contralateral premotor cortex （ PMC ）, bilaterally in the supplementary motor area （SMA） and in the ipsilateral cerebellum. The activated brain areas were centered on the contralateral SMC and PMC and located more forward during active movement than during passive movement. The contralateral SMC was the most strongly and the most frequently activated brain area. The contralateral posterior parietal cortex （PPC） was less relevant to the hand movements. Unlike active movement, passivemovement activated more areas in the posterior central gyrus than in the anterior central gyrus. Conclusions Both active and passive movement significantly activate the brain areas which are responsible for hand movement, but there are some differences in the locations of the cortex areas activated and in the incidence activation except in the contralateral SMC.

关 键 词：血氧水平依赖性功能性磁共振成像 主动运动 被动运动 感觉运动区 运动前区 辅助运动区 

分 类 号：R445.2[医药卫生—影像医学与核医学]