STAMP2基因多态性与新疆维吾尔族人原发性高血压的相关性研究  

Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population

作　　者：毕云伟[1] 王昌敏[2] 严治涛[3] 李南方 郭艳英[1] 王红梅 姚晓光 梁登攀 

机构地区：[1]新疆维吾尔自治区人民医院高血压科,乌鲁木齐830054 [2]新疆维吾尔自治区人民医院特检科,乌鲁木齐830054 [3]新疆医科大学研究生院 [4]新疆高血压诊断治疗研究中心

出　　处：《中华医学遗传学杂志》2011年第1期64-68,共5页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金（30850006）

摘　　要：目的探讨STAMP2基因功能区多态位点与新疆维吾尔族人原发性高血压的相关性。方法采用以流行病学调查为基础的病例-对照研究，选取2047个维吾尔族人（包括810例高血压病患者和1237名对照）作为研究对象。首先在小样本维吾尔族高血压患者中测序筛查STAMP2基因功能区的变异位点，选取代表性变异位点应用TaqMan-PCR在大样本人群中进行基因型鉴定及病例一对照关联研究。结果STAMP2基因的3个代表性变异位点rs8122、rs1981529及rs34741656基因型及等位基因分布在高血压组与对照组中差异无统计学意义（P〉0．05）。Logistic回归分析发现3个位点不是高血压患病的危险因素（P〉0．05）。rs8122、rs1981529及rs34741656不同基因型间收缩压、舒张压水平差异无统计学意义（P〉0．05）。单倍型基因频率分布在高血压组与对照组中差异无统计学意义（P〉0．05）。结论STAMP2基因3个代表性单核苷酸多态性（rs8122、rs1981529及rs34741656）可能与新疆维吾尔族人原发性高血压无关。Objective To investigate the relationship between the genetic polymorphisms of the six transmembrane protein of prostate 2 gene （STAMP2） and essential hypertension in Xinjiang Uygur population. Methods The sequences of STAMP2 gene functional region were sequenced in Xinjiang Uygur population with hypertension. The representative variations selected were genotyped by TaqMan-PCR method in 2047 Uygur individuals, including 810 patients with hypertension and 1237 healthy subjects. The association of the genetic variations of the STAMP2 gene with hypertension in Uygur was analyzed. Results In the three representative variations （rs8122, rs1981529 and rs34741656） genotyped, there were no significant differences in genotype distribution and allele frequencies between the essential hypertension and control groups （P〉0.05）. In ANCOVA analysis, none of the polymorphisms was significantly associated with systolic blood pressure and diastolic blood pressure（P〉0.05）. There were no significant differences in haplotype frequencies between the two groups either（P〉0. 05）. Conclusion There was no association of the three polymorphisms （rs8122, rs1981529 and rs3741656） in the STAMP2 gene with essential hypertension in Xinjiang Uygur population.

关 键 词：STAMP2基因 遗传多态性 新疆维吾尔族 原发性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]