血清硫脑苷脂与冠心病的相关性  

Correlated study between serum sulfatide and coronary heart disease

作　　者：李刚[1] 胡蕊[2] 刘惠良[1] 陈淑霞[1] 张至[1] 吕妍坤[1] 薛华[1] 

机构地区：[1]河北省人民医院心脏中心,石家庄050051 [2]河北医科大学第二医院检验科

出　　处：《临床心血管病杂志》2011年第1期16-18,共3页Journal of Clinical Cardiology

摘　　要：目的:对冠心病患者血清硫脑苷脂进行分析测定,观察其与冠心病类型的相关性。方法:入选冠心病患者70例(其中不稳定型心绞痛患者43例,稳定型心绞痛患者27例)和正常对照组28例,采用高效基质辅助激光解析电离飞行时间质谱法对以上人群血清硫脑苷脂进行观测。结果:与正常对照组[(8.03±0.99)μmol/L]比较,冠心病组[(11.35±2.80)μmol/L]血清硫脑苷脂浓度明显增高(P<0.01),而且不稳定型心绞痛亚组[(11.95±2.80)μmol/L]的血清硫脑苷脂浓度比稳定型心绞痛亚组[(10.42±2.27)μmol/L]也明显增高(P<0.05)。结论:血清硫脑苷脂浓度随冠状动脉病变的发生而升高,并与动脉粥样硬化斑块的稳定性相关。血清硫脑苷脂的浓度可能对冠心病的诊治有重要参考价值。Objective：To detect the level of serum sulfatide in patients with coronary heart disease（CHD） and evaluate its clinical correlation with angina pectoris.Method：Ninety-eight hospitalized patients were enrolled in this research.43 cases were unstable angina pectoris（UAP）,27 cases were stable angina pectoris（SAP）,28 cases were normal controls.Serum sulfatide was measured with matrix assisted laser desorption ionization time of flight mass spectrometry method.Result：The concentration of serum sulfatide in patients with CHD[（11.35±2.80）μmol/L]was significantly higher than that in normal control group（8.03±0.99）μmol/L,P0.01].Further,the patients with USP [（11.95±2.80）μmol/L]had significantly higher serum sulfatide concentration as compared to the patients with SAP [（10.42±2.27）μmol/L,P0.05].Conclusion：The concentration of serum sulfatide was increased in patients with coronary heart disease and was related to the stability of atherosclerosis plaques.Serum sulfatide level perhaps had potential indication in diagnosing and treating coronary artery diseases.

关 键 词：冠状动脉疾病 血清硫脑苷脂 不稳定型心绞痛 稳定型心绞痛 动脉粥样硬化 

分 类 号：R543.3[医药卫生—心血管疾病]