冠心病患者上消化道出血后停用阿司匹林与近期心血管事件的关系  

Evaluation of short term cardiovascular events in patients with coronary heart disease after aspirin withdrawal for upper gastrointestinal bleeding

作　　者：刘亚军[1] 李文放[2] 林茂恩 王智兰[1] 

机构地区：[1]南通市中医院急救科,江苏南通226600 [2]上海长征医院急救科 [3]浙江瑞安市中医院急救科

出　　处：《临床心血管病杂志》2011年第1期19-21,共3页Journal of Clinical Cardiology

摘　　要：目的:回顾性分析冠心病患者因上消化道出血后停用阿司匹林与近期心血管事件发生的关系。方法:对43例冠心病患者因上消化道出血行常规治疗,同时停用阿司匹林,并于入院即刻及停用阿司匹林第7天、14天时间点监测血小板聚集率、CD62p表达率,观察1个月内心血管事件发生情况。结果:停用阿司匹林后第7天、14天血小板聚集率及CD62p表达率均明显升高(P<0.001),第14天血小板聚集率、CD62p表达率与第7天相比稍有增高(P均>0.05),停药后1个月内共发生心血管事件7例(16.28%)。结论:上消化道出血后停用阿司匹林后血小板活化增强,近期心血管事件明显增多。Objective：To evaluate short term cardiovascular events in patients with coronary heart disease（CHD） after aspirin withdrawal for upper gastrointestinal bleeding.Method：43 CHD patients with upper gastrointestinal bleeding were enrolled.The platelet aggregation rate and the expression of CD62p were analyzed at day 1,day 7 and day 14 by flow cytometry after admission,and the cardiovascular events were observed in the following month.Result：The platelet aggregation rates and the expression levels of CD62p at day 7 and day 14 were significantly higher than those at day 1（P0.001,P0.001,respectively）,the platelet aggregation rates and the expression levels of CD62p at day 14 were slightly higher than those at day 7（P0.05,P0.05,respectively）,and there were 7 cases of cardiovascular events in the following month（16.28%）.Conclusion：The activation of platelet increased after asprin withdrawl in CHD patients with upper gastrointestinal bleeding,suggesting a higher risk of short term cardiovascular events.

关 键 词：冠心病 阿司匹林 上消化道出血 血小板聚集率 CD62P 心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]