N末端脑利钠肽原和C反应蛋白在老年舒张性心力衰竭诊治中的评价  

Diagnostic and therapic evaluations of N-terminal pro B-type natriuretic peptide and C-reactive protein in geriatric diastolic heart failure

作　　者：梁魏昉[1] 贾玲[1] 

机构地区：[1]郑州大学第一附属医院老年心血管科,郑州450052

出　　处：《临床心血管病杂志》2011年第1期44-46,共3页Journal of Clinical Cardiology

摘　　要：目的:测定老年舒张性心力衰竭(DHF)患者治疗前、后血N末端脑利钠肽原(NT-ProBNP)和C反应蛋白(CRP)的水平,探讨老年DHF时NT-ProBNP和CRP的变化及其意义。方法:选取59例经临床治疗后心力衰竭改善的老年DHF患者,根据Lester等〔1〕介绍的美国DHF的超声诊断方法,按DHF的分级分组:弛缓受损组(25例),假性正常化充盈组(19例),限制性充盈组(15例),并选取22例心功能正常者作为对照组。监测DHF患者治疗前、后的血NT-ProBNP和CRP水平。结果:①老年DHF患者的NT-ProBNP和CRP值明显高于对照组(P<0.05)。②老年DHF患者假性正常化充盈组的NT-proBNP和CRP值显著高于弛缓受损组(P<0.05),限制性充盈组的NT-proBNP和CRP值显著高于弛缓受损组及假性正常化充盈组(P<0.05)。③老年DHF患者治疗后NT-ProBNP和CRP均显著下降(P<0.05)。结论:血浆NT-ProBNP和CRP在老年DHF患者中明显升高,且升高幅度随着舒张功能不全程度的加重而升高,对疗效观察和病情转归有一定的实用的临床价值。Objective：To analyze the change and significance of plasma N-terminal pro B-type natriuretic peptide（NT-ProBNP） and serum C-reactive protein（CRP） in geriatric diastolic heart failure（DHF） and further illustrate clinical value measuring plasma NT-ProBNP and serum CRP at the same time.Method：Collected 59 diastolic DHF patients as research target which heart function was obviously improved by clinical treatment.According to the level of left ventricular filling by ultrasonic cardiogram（UCG） detected,25 patients were the abnormal relaxation group,19 patients were the pseudonormal filling group,and 15 patients were the restrictive filling group.22 patients of normal cardiac function as control group.Plasma NT-ProBNP and serum CRP levels were measured before and after treatment in geriatric DHF groups.Result：①The level of plasma NT-proBNP and serum CRP in geriatric DHF were significantly higher than that in control group（P0.05）.②The level of plasma NT-proBNP and serum CRP in geriatric DHF patients with the pseudonormal filling group were significantly higher than that in abnormal relaxation group（P0.05）.The restrictive filling group has significantly higher than the abnormal relaxation group and the pseudonormal filling group（P0.05）.Plasma NT-proBNP and serum CRP in patients with different cardiac function were significantly higher than that in control group（P0.05）.③Plasma NT-proBNP and serum CRP in geriatric DHF patients with different cardiac function were significantly decreased by clinical treatment（P0.05）.Conclusion：The levels of plasma NT-proBNP and serum CPR in diastolic DHF were significantly higher than those in control group.The levels of plasma NT-proBNP and serum CPR coincided with the levels of diastolic DHF.

关 键 词：老年舒张性心力衰竭 C反应蛋白 N末端脑利钠肽原 

分 类 号：R541.6[医药卫生—心血管疾病]