胞膜窖与钾离子通道  

Caveolae and Potassium Channels

作　　者：吴争[1] 刘佳[1] 张楠[1] 崔玉影[1] 邹伟[1,2] 

机构地区：[1]辽宁师范大学生命科学学院,大连116029 [2]辽宁师范大学辽宁省生物技术和分子药物研发重点实验室,大连116029

出　　处：《中国生物化学与分子生物学报》2011年第1期1-5,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.30570225)资助项目~~

摘　　要：胞膜窖(caveolae)是细胞质膜内陷形成的凹陷小窝,参与细胞内多种重要的生理活动的调节.近年研究表明,电压门控钾离子通道、钙离子激活的电压门控钾离子通道和ATP敏感的钾离子通道等多种钾离子通道家族成员的功能调节与胞膜窖有关.本文概括介绍了胞膜窖和钾离子通道调节关系的研究进展.Caveolae are small invaginations of the plasma membrane in many cell types and involved in several important physiological fuctions.Recently,many potassium channels,such as voltage-gated K ＋ channel,Ca2 ＋-activated K ＋ channel and ATP sensitive K ＋ channel,have been found in caveolae and play an important role in different signal transduction pathways.Here we mainly review the location of potassium channels in caveolae and the regulation of potassium channels by caveolins.

关 键 词：胞膜窖 窖蛋白 钾离子通道 信号转导 

分 类 号：Q257[生物学—细胞生物学] Q735