^(32)P敷贴治疗直肠尖锐湿疣及临床疗效分析  

A ^(32)P application device for the treatment of condyloma acuminatum in the rectum

作　　者：马玉波[1] 刘怡文[2] 顾爱春[1] 徐枫[1] 刘平安[1] 袁素芬[1] 翟春桃[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院核医学科,上海200001 [2]上海交通大学医学院附属仁济医院皮肤科,上海200001

出　　处：《中华男科学杂志》2011年第1期47-51,共5页National Journal of Andrology

摘　　要：目的:尝试32P敷贴治疗直肠尖锐湿疣,并对比微波方法考察其临床疗效。方法:直肠尖锐湿疣患者107例,随机分为敷贴组46例,以32P为敷贴用放射性核素,借助自制敷贴器为载体,放置于直肠内固定,对直肠内尖锐湿疣病灶进行敷贴治疗。微波组61例,局麻下微波烧除疣体。两组均随访3个月以上,对比分析临床疗效,考察敷贴器的稳定性和可靠性。结果:敷贴组治愈率84.8%,复发率13.0%,不良反应发生率8.7%;微波组则分别为40.3%、55.7%、75.4%。两组比较,治愈率、复发率、不良反应发生率均有统计学差异(P<0.01)。结论:通过自制敷贴器,以32P敷贴治疗直肠尖锐湿疣,取材和方法简便,安全可靠,复发率低,不良反应少,患者乐于接受,是一种较成功和有效的治疗方法。Objective：To investigate the use of a ^32P application device（AD） in the treatment of condyloma acuminatum（CA） in the rectum,and to compare its clinical effect with that of the microwave therapy.Methods：This study included 107 cases of CA in the rectum,99 males and 8 females,aged 21-58（33.6±9.4） years.Forty-six of the patients（the AD group） were treated with a self-made ^32P application device,which,as a tube-shaped carrier of radionuclide ^32P colloid,was fixed in the rectum at the diseased part for medication at 4.9-8.2 Gy for 3-5 hours once and 1-2 times a week.The other 61（the microwave group） were treated by microwave burning under local anesthesia.Both groups of patients were followed up for over 3 months for comparison of the therapeutic results and observation of the stability and reliability of the 32P application device.Results：The rates of cure,reoccurrence and adverse reaction were 84.8%,13.0% and 8.7% in the AD group,compared with 40.3%,55.7% and 75.4% in the microwave group,with statistically significant differences between the two groups（P0.01）.Conclusion：The ^32P application device,with its advantages of low cost,easy operation,good effect,high safety and reliability,low recurrence,fewer adverse events and good acceptability,is highly valuable for the treatment of CA in the rectum.

关 键 词：尖锐湿疣 直肠 ^32P 敷贴治疗 微波疗法 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]