增强丙型肝炎病毒DNA疫苗免疫原性的策略  

Progress in the development and immunogenicity improvement of DNA vaccine against chronic HCV infection

作　　者：殷霄[1] 文波[2] 谭文杰[1] 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所,北京102206 [2]吉林大学生命科学学院,长春130012

出　　处：《临床肝胆病杂志》2011年第1期32-35,共4页Journal of Clinical Hepatology

基　　金：国家"863"计划专题项目(2007AA02Z455);国家传染病科技重大专项(2009ZX10004-715)

摘　　要：当前全世界有超过1.7亿慢性丙型肝炎(CHC)感染者,目前尚无有效的疫苗。最近丙型肝炎病毒(HCV)实验性疫苗的研制有不少进展。本文综述了增强HCV DNA疫苗免疫原性的策略及相关进展。More than 170 million people are currently affected by chronic hepatitis C virus（HCV） infection worldwide.Currently,there is no vaccine available.There are many HCV experimental vaccines developed and progressed recently.Here,we would discuss strategies of enhancing immunogenicity of DNA vaccine and review some progress towards development of DNA vaccine against chronic HCV infection.

关 键 词：肝炎病毒属 疫苗 DNA 免疫原性 

分 类 号：R392[医药卫生—免疫学]