软骨组织工程研究新进展  

RECENT PROGRESS OF RESEARCHES IN CARTILAGE TISSUE ENGINEERING

作　　者：靳小兵[1] 

机构地区：[1]美国密歇根大学口腔医学院生物医学材料工程系

出　　处：《中国修复重建外科杂志》2011年第2期187-192,共6页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的对近年来软骨组织工程相关研究新进展进行综述,讨论组织工程软骨构建存在的问题。方法查阅近年软骨组织工程领域相关文献,总结最新进展。结果部分软骨组织工程技术已应用于临床;诱导多能干细胞为种子细胞获取提供了新选择;从结构和功能模拟天然基质是目前支架材料研发的热点;诱导自体细胞迁移归巢再生软骨可以避免外源性细胞移植,可能成为新的发展方向。结论干细胞技术的发展、新型仿生支架材料的研发和细胞因子的合理利用进一步推动了组织工程软骨的临床应用。Objective To review the recent progress of the researches in the field of cartilage tissue engineering,and to discuss the challenges in construction of tissue engineered cartilage.Methods Literature related with cartilage tissue engineering was reviewed and analyzed.Results Some techniques have been applied in clinical.As far as the seeding cells,induced pluripotent stem cells have attracted much more attention.Current strategies of scaffold designing are trying to imitate both component and structure of natural extracellular matrix.Cartilage regeneration through the autologous cell homing technique eliminate the transplantation of exotic cells and has become the hot topic.Conclusion Successful treatment of the damaged cartilage using tissue engineering method will depend on the advances of stem cell technology development,biomimetic scaffolds fabrication and proper application of growth factors.

关 键 词：软骨组织工程 干细胞 支架 细胞因子 仿生 细胞归巢 

分 类 号：R318.08[医药卫生—生物医学工程]