低出生体重儿危险因素病例对照研究  

A Case-Control Study on Risk Factors of Low Birth Weight Infant

作　　者：刘银梅[1] 沈月平[1] 罗小明[2] 刘娜[1] 胡文斌[1] 赵瑶[1] 

机构地区：[1]苏州大学医学部放射医学与公共卫生学院,江苏苏州215123 [2]昆山市妇幼保健所,江苏昆山215300

出　　处：《实用妇产科杂志》2011年第1期39-42,共4页Journal of Practical Obstetrics and Gynecology

基　　金：国家自然科学基金(编号:3082176);苏州大学医学发展基金重点项目(编号:EE126765)

摘　　要：目的:探讨低体重儿发生的相关危险因素,为降低低体重儿出生率提供科学依据。方法:采用严格设计1:2配比的病例对照研究方法,对2004～2009年苏州地区的631例低体重儿和1262例正常体重儿相关流行病学资料进行分析。结果:经济状况差(OR=2.01,95%CI1.35～4.81)、母亲肝病史(OR=2.73,95%CI1.01～7.37)、母亲糖尿病家族史(OR=9.13,95%CI1.01～82.15)、自然流产史(OR=1.41,95%CI0.97～2.04)、孕前6个月服避孕药(OR=3.31,95%CI1.07～10.27)、孕期营养差(OR=5.93,95%CI3.24～10.89)、孕早期阴道流血(OR=1.42,95%CI1.03～1.96)、孕期体重增加偏少(<9kg)(OR=3.74,95%CI1.92～5.90)、孕期检查次数少(<5次)(OR=3.52,95%CI2.49～7.11)、妊娠期高血压疾病(OR=3.23,95%CI2.02～5.17)、多胎妊娠(OR=10.02,95%CI6.17～16.27)、贫血(OR=2.34,95%CI1.59～3.43)、血小板计数低(OR=2.16,95%CI1.47～3.16)是低出生体重儿发生的危险因素,父母文化程度高是保护因素。结论:低出生体重儿的发生和多种因素有关,有针对性地开展防治工作是降低低出生体重儿发生率的有效措施。Objective：To investigate the risk factors of low birth weight （LBW） infant and to provide the scientific evidence of reducing the birth rate of LBW. Methods ：A strictly designed 1：2 case-control study,with 631 LBW infants and 1262 normal birth weight infants involved,was performed in Suzhou during 2004 to 2009 to analyze the epidemiologic information. Results： Main risk factors of LBW included poor economic conditions （ OR=2.01,95%CI 1.35-4.81 ） ,the history of mother＇s liver disease （ OR =2.73,95%CI 1.01 - 7.37）, mother family history with diabetes （ OR = 9.13,95% CI 1.01 - 82.15 ）, spontaneous abortion （ OR = 1.41,95%CI 0.97 -2.04） ,oral contraception within 6 months before pregnancy（ OR=3.31,95%CI 1.07-10.27）, poor nutrition status during pregnancy （ OR = 5.93,95% CI 3.24 - 10.89 ）, vaginal bleeding during early pregnancy （ OR = 1.42,95% CI 1.03 - 1. 96）, small weight gain during pregnancy （ 〈 9 kg） （ OR = 3.74,95%CI 1.92 -5.90）, few times of pregnancy check-up （ 〈 5 times） （OR = 3.52,95% CI 2.49 - 7.11 ）, gestational hypertension （ OR = 3.23,95% CI 2.02 - 5.17 ）, multiple pregnancies （ OR = 10.02,95% CI 6.17 - 16.27）, anemia （ OR = 2.34,95% CI 1.59 - 3.43）, low platelet count （ OR = 2.16,95% CI 1.47 - 3.16）. Parent with high education level was a protective factor. Conclusions：The incidence of LBW is associated with many factors. Intended measures to prevent those risk factors could be effective in reducing the incidence of LBW.

关 键 词：出生时低体重 病例对照研究 危险因素 条件LOGISTIC回归 

分 类 号：R714[医药卫生—妇产科学]