环境硒水平与农村老年人群认知能力的相关性研究  

Correlation between environmental selenium levels and cognitive ability among rural elderly population

作　　者：边建朝[1] 秦启亮[1] 云中杰[1] 刘源[1] 刘传蛟[1] 宋术亮[1] 骆效宏[1] 翟丽屏[1] 高杰[1] 梁超轲[2] Sujuan GAO 

机构地区：[1]山东省地方病防治研究所,济南250014 [2]中国疾病预防控制中心环境与健康相关产品安全所 [3]美国印第安纳大学医学院医学生物统计系

出　　处：《中国地方病学杂志》2011年第1期84-87,共4页Chinese Jouranl of Endemiology

基　　金：美国国立卫生院基金（NIHR01AG19181-01A2）;山东省医药卫生科技发展计划（200387）

摘　　要：目的 探讨老年人群认知能力与环境硒水平的相关性,验证体内不同硒水平对老年人群认知能力的影响.方法 选择山东省外环境硒水平不同的淄川区和高密市为调查点,其中淄川区为适硒[硒摄入量（46.73±24.36）mg·kg-1·d-1]地区,高密市为低硒[硒摄入量（11.66±4.72）mg·kg-1·d-1]地区.采用分层抽样方法,分别抽取终身居住于当地年龄≥65岁的农村老年人各500人,利用膳食摄入量调查表,对老年人进行近1年的回顾性膳食调查,计算每日硒总摄入量.采用美国印第安纳大学提供的社区痴呆筛查量表（CSID）、故事记忆测试、动物流畅性测验评定老年人群的认知能力;采用美国老年痴呆症登记联盟（CERAD）词表中提供的方法,对老年人群进行学习测试、学习记忆测试;采用现场采访评定方式,通过问卷调查形式获得老年人群认知能力资料,分析体内硒水平与老年人群认知能力之间的相关性.采集老年人群指甲和静脉血,应用荧光分光光度法检测指甲硒和血硒水平.结果 适硒与低硒地区老年人群硒摄入量[（46.73±24.36）、（11.66±4.72）mg.kg-1·d-1]、指甲硒[（0.605±0.163）、（0.405±0.086）mg/kg]和血硒[（147.44±17.42）、（117.38±22.48）μg/L]组间比较差异有统计学意义（U值分别为31.59、25.00、23.67,P均＜0.01）;硒摄入量与指甲硒和血硒、指甲硒与血硒之间存在正相关（r值分别为0.51、0.46、0.60,P均＜0.01）.老年人群体内硒水平与认知能力,除动物名词叙述测试外,CSID总计分、故事记忆、回忆测试、学习记忆测试组间比较差异有统计学意义（F值分别为2.56、9.18、7.48、4.42,P＜0.05）;剔除可能混杂因素的影响后,除学习记忆测试外,老年人群体内硒水平与CSID总计分、故事记忆、动物流畅、学习测试有明显的正相关（r值分别为0.076、0.138、0.042、0.107,P＜0.05或＜0.01）.结论 环境硒水平与老年人群的认Objective To explore the correlation between environmental selenium（Se） levels and cognitive ability among rural elderly population, and the effect of Se on cognitive skill of the elderly. Methods Two study sites（Zichuan district and Gaomi city of Shandong） with different environmental Se levels were selected according to rural elderly people ≥ 65 years were extracted by stratified random sampling method in each site. A retrospective survey was carried out using dietary intake questionnaire for the elderly for the past 1 year, and their daily total Se intake was calculated. Questionnaire was also used to obtain cognitive skill information in the elderly people. The Community Screening Instrument for Dementia, the Consortium to Establish a Registry for Alzheimer＇s Disease （CERAD） Word List Learning Test, the Indiana University （IU） Story Recall Test, the Animal Fluency Test, and the IU Token Test were applied to assess the cognitive ability. Se level in these samples was analyzed. Correlation between the Se levels of environment and those of human body were analyzed statistically. Results There were 0.163）, （0.405 ± 0.086）]mg/kg and nail Se[（147.44 ± 17.42）, （117.38 ± 22.48）μg/L]between the two groups （U = 31.59, 25.00, 23.67, all P 〈 0.01 ）. There were positive correlation among the nail Se, environmental Se and Se in all subjects（r = 0.51,0.46, 0.60, all P 〈 0.01 ）. The differences of the CSID total score, the CERAD Word List Learning Test, the CERAD Word List Recall Test and the IU Story Recall Test between the two sites were statistically significant（F = 2.56, 9.18, 7.48, 4.42, all P 〈 0.05）, excluding the Indiana University Story Recall Test.After eliminating possible confounding factors, the Se levels and the CSID total score, the IU Story Recall Test, the Animal Fluency Test and the IU Story Token Test had a significantly positive correlation （r = 0.076, 0.138, 0.042,0.107, P 〈 0.05 or 〈 0.01 ）, excluding the CERAD Word List Learning Test. Conc

关 键 词：老年人 硒 认知能力 

分 类 号：R1[医药卫生—公共卫生与预防医学]