海岛居民甲状腺疾病和碘营养状况的关系  

Association of iodine nutrition and thyroid health conditions among residents in Zhoushan archipelago

作　　者：张永奎[1] 刘晓光[1] 竺王玉[1] 周世权[1] 王晔恺[1] 胡晓斐[1] 郑笑娟[1] 赵臣银[1] 袁惠萍[1] 

机构地区：[1]舟山市人民医院,316004

出　　处：《中华内分泌代谢杂志》2011年第1期28-31,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家星火计划项目（2008GA700174）;浙江省科技厅面上项目（2008C33043）

摘　　要：目的 调查舟山海岛地区居民甲状腺疾病和碘营养状况,分析二者的相互关系.方法 通过整群随机抽样的方法选取了3284名舟山成年居民进行了尿碘检测,并进行流行病学问卷调查、甲状腺B超检查、甲状腺功能测定.结果 舟山海岛地区成年居民尿碘中位数为226.0μg/L,其中城镇居民320.7 μg/L、盐民122.2 μg/L、农民188.9 μg/L、渔民193.6 μg/L、僧侣271.7 μg/L.舟山地区3284名居民弥漫性甲状腺肿、结节性甲状腺肿、胶质性甲状腺肿、甲状腺腺瘤、甲状腺癌、甲状腺功能亢进（甲亢）、亚临床甲亢、甲状腺功能减退（甲减）、亚临床甲减的患病率分别为1.7%、25.3%、8.7%、0.2%、0.4%、0.5%、0.8%、0.03%和1.0%,甲状腺过氧化物酶抗体（TPOAb）阳性率为9.5%.甲状腺疾病患病率女性明显高于男性（P＜0.05）,且随年龄的增长而增高（P＜0.05）.经logistic回归模型分析甲状腺疾病患病率与年收入、食用海产品、吸烟史、饮酒史、饮茶史、尿碘值等均无明显相关性（P＞0.05）.结论 舟山地区居民碘摄入充足,是否实施全民食盐加碘值得商榷;舟山海岛地区甲状腺疾病的患病率较高可能与碘过量有关.Objective To investigate iodine nutrition and thyroid health status among residents in Zhoushan archipelago, and to analyse their relationship.Methods A total of 3 284 residents in Zhoushan archipelago were surveyed by questionnaire and their thyroids were examined by B-mode ultrasound.The levels of urinary iodine and thyroid function were detected.Results The median level of urinary iodine in 3 284 residents was 226.0 μg/L, being 320.7 μg/L in citizens, 188.9 μg/L in farmers, 122.2 μg/L in salt-makers, 193.6 μg/L in fishers, and 271.7 μg/L in buddhist.The prevalence of diffuse goiter, nodular goiter, colloid goiter, thyroid adenoma, thyroid carcinoma, hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, subclinical hypothyroidism, and positve rate of TPOAb were 1.7% ,25.3% ,8.7% ,0.2% ,0.4% ,0.5% ,0.8% ,0.03%,1.0% ,and 9.5% repectively.The prevalence of thyroid diseases was increasing with aging, and higher in women than in men （P〈0.05）.There was no significant relationship of the thyroid diseases with seafood, smoking,drinking, and tea （P〉0.05）.Conclusions The citizens of Zhoushan archipelago have adequate iodine intake.It is pertinent to discuss Universal Salt Iodization.Excessive iodine intake may contribute to the high prevalence rate of thyroid diseases in Zhoushan.

关 键 词：甲状腺 碘 流行病学 

分 类 号：R581[医药卫生—内分泌]