女童特发性中枢性性早熟及正常女性青春发育各期血浆kisspeptin水平研究  

Plasma kisspeptin levels in normal female pubertal stages and in girls with idiopathic central precocious puberty

作　　者：马晓宇[1] 倪继红[1] 刘玥隽[2] 陈少科[3] 王伟[1] 

机构地区：[1]上海交通大学附属瑞金医院儿内科,200025 [2]上海交通大学附属瑞金医院内分泌科,200025 [3]广西壮族自治区妇幼保健院

出　　处：《中华内分泌代谢杂志》2011年第1期36-39,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的 研究女童特发性中枢性性早熟（ICPP）及正常女性青春发育各期血浆kisspeptin水平,并探讨以此鉴别ICPP和单纯性乳房早发育（premature thelarche,PT）的意义.方法 女童共92名,女青年18名,其中ICPP 10例、PT12例、正常青春发育Tanner Ⅰ～Ⅴ期各16～19名.采用酶联免疫吸附方法（ELISA）检测血浆kisspeptin.结果 血浆kisspeptin水平ICPP组明显高于PT组[（1.73±0.23对1.43±0.29）ng/ml,P＜0.05];正常青春发育kisspeptin水平从Tanner Ⅱ期至Tanner Ⅴ期逐渐下降,其中以Tanner Ⅱ期最高;Tanner Ⅳ、Ⅴ期明显低于TannerⅠ、Ⅲ期（P＜0.01）.结论 正常女性青春发育期血浆kisspeptin 水平以TannerⅡ期最高,检测其水平对于临床鉴别ICPP与PT有一定意义.Objective To investigate the pattern of plasma kisspeptin levels in normal female during various pubertal Tanner stages and the girls with idiopathic central precocious puberty（ICPP） or with premature thelarche（PT）, and to evaluate the significance of detecting plasma kisspeptin levels as a new criterion for early differentiation between ICPP and PT.Methods Each study group of normal pubertal females with Tanner stage Ⅰ to Ⅴ comprised 16 to 19 individuals.The levels of plasma kisspeptin were also detected in girls with ICPP（n= 10）or PT（n = 12）.The plasma kisspeptin levels were detected by enzyme-linked immunosorbent assay （ELISA）.Results The level of kisspeptin was significantly higher in ICPP group than in that of PT group [（1.73±0.23 vs1.43±0.29） ng/ml, P〈0.05].Among the normal pubertal females, the level of kisspeptin decreased gradually from Tanner stage Ⅱ to Tanner stage Ⅴ, being highest in Tanner stage Ⅱ [（1.73±0.22） ag/ml] ,lower in stage Ⅳ and Ⅴ than in stage Ⅰ and Ⅲ （P〈0.01）.Conclusions Plasma kisspeptin level was the highest during Tanner stage Ⅱ in normal female pubertal development.It is significant to detect plasma kisspeptin level for the differential diagnosis of ICPP and PT.

关 键 词：KISSPEPTIN 特发性中枢性性早熟 单纯性乳房早发育 Tanner分期 女性 

分 类 号：R725.8[医药卫生—儿科]