自固化硅羟基磷灰石骨水泥的制备及性能研究  

Study on Preparation and Properties of Self-setting Silicon Hydroxyapatite Bone Cement

作　　者：苏佳灿[1] 曹烈虎[1] 禹宝庆[1] 王志伟[1] 陈晓[1] 李明[1] 

机构地区：[1]上海市第二军医大学附属长海医院骨科,上海200433

出　　处：《无机材料学报》2011年第1期55-60,共6页Journal of Inorganic Materials

基　　金：上海市科委纳米专项基金(0852nm04300);上海市人事局人才发展资金(2009003);中国博士后基金(20100470756)~~

摘　　要：采用磷酸四钙和磷酸氢钙为羟基磷灰石水泥(HAC)粉末,5wt%硅酸钠水溶液为固化液,制备了硅羟基磷灰石水泥(s-HAC).结果显示:s-HAC的凝结时间和抗压强度性能明显优于以水为固化液的HAC.XRD和IR结果分析表明:s-HAC的最终水化产物为硅羟基磷灰石.s-HAC在Tris-HCl缓冲溶液中不仅能够释放出Ca、P离子,而且还能释放出Si离子,s-HAC的体外降解性优于HAC.细胞培养实验显示:MG_(63)细胞不仅能够在s-HAC和HAC表面粘附并保持正常的细胞形态;而且MG_(63)细胞在s-HAC上的光密度(OD)值和碱性磷酸酶(ALP)活性明显高于HAC,这说明s-HAC能促进成骨细胞增殖和分化.Silicon hydroxyapatite cement（s-HAC） was prepared by using the mixed powders of tetracalcium phosphate and dicalcium phosphate anhydrous,and 5wt%sodium silicate water solutions as cement liquid.The results show that the setting time of s-HAC is shorter than hydroxyapatite cement（HAC）,and the compressive strength of s-HAC is higher than HAC in the same situation.The XRD results reveal that the finally hardening product of s-HAC is hydroxyapatite structure,which is similar to that of HAC.The s-HAC in the could release calcium （Ca）,phosphorus（P） and silicon（Si） ions.The in vitro degradability of s-HAC in Tris-HCl solution is better than that of HAC.The cell culture experimental results indicate that the cell can attach on both the surfaces of s-HAC and HAC,and have good cell morphology.The optical density（OD） and alkaline phosphate（ALP） activity of MG（63） cells on s-HAC are significantly higher that that of HAC,indicating that the s-HAC could promote the cell proliferation and differentiation.

关 键 词：硅羟基磷灰石 水泥 降解 细胞增殖 分化 

分 类 号：TB383[一般工业技术—材料科学与工程]