介孔生物活性玻璃装载和释放抗癌药物表阿霉素的研究  

Study on the Loading and Releasing Behavior of Epirubicin Hydrochloride from Mesoporous Bioactive Glasses(MBGs)

作　　者：周艳玲[1] 冯新星[1] 翟万银[1] 常江[1] 

机构地区：[1]中国科学院上海硅酸盐研究所,上海200050

出　　处：《无机材料学报》2011年第1期68-72,共5页Journal of Inorganic Materials

基　　金：国家重点基础研究发展973计划(2005cB522704);国家自然科学基金(30730034);上海市基础研究重点项目(08JC1420800);国家高技术研究发展863计划(2007AA032317)~~

摘　　要：将介孔58S生物活性玻璃(m58S)作为抗癌药物载体评价了其对表阿霉素的装载量和释放性能.实验结果表明,m58S对亲水性药物表阿霉素的药物装载量为40%,是普通溶胶-凝胶58S生物活性玻璃的3倍多,并且具有更长效的缓释特性.研究还发现释放介质的pH值对表阿霉素的释放速率有很大影响,pH值越低,表阿霉素分子从载体材料中释放出的速率越快.因此,介孔生物活性玻璃是一种高效的药物缓释载体,且药物释放速率受释放介质pH值影响,有望成为药物控释型骨修复材料.Mesoporous bioactive glasses m58S were loaded with an anticancer drug-Epirubicin hydrochloride（EPI） and the release of the drug from the glasses was evaluated.The drug loading capacity of m58S for EPI was 40%, which was three times higher than that of conventional Sol-Gel bioactive glasses 58S.In phosphate buffered saline （PBS）,the m58S-EPI system showed a sustained release behavior.Furthermore,the release rates from the EPI-m58S system increased with the decrease of pH values of the release medium.The results suggest that m58S is an effective anticancer drug carrier and its pH-related release behavior suggests that it has potential for design of controlled drug delivery bone grafting materials.

关 键 词：生物活性玻璃 介孔材料 药物载体 

分 类 号：R318[医药卫生—生物医学工程]