交替循环浸泡在TiO_2纳米管管内填充类骨磷灰石  

Filling TiO_2 Nanotubes with Biological Apatite by Alternative Loop Immersion Method

作　　者：俞佳[1] 肖秀峰[1] 梁建鹤[1] 刘榕芳[1] 王春燕[1] 毛丹[1] 

机构地区：[1]福建师范大学化学与材料学院,福州350007

出　　处：《无机材料学报》2011年第1期78-84,共7页Journal of Inorganic Materials

基　　金：国家自然科学基金(50970887;30600149);卫生部科学研究基金(WKJ 2008-02-037);教育部重点项目(209061);福建省纳米材料重点实验室基金(NM10-03)~~

摘　　要：采用"交替循环浸泡法(ALIM)"在TiO_2纳米管管内填充类骨磷灰石,使磷灰石涂层由层状结构变为嵌入式结构,并考察填充量与TiO_2纳米管结构间的关系,通过模拟体液浸泡实验评价其生物活性.结果表明,甘油体系(60V电压)中制备的纳米管填充效果最好;无定型的TiO_2纳米管相比锐钛矿相的TiO_2纳米管更能诱导类骨磷灰石的填充;采用ALIM于TiO_2纳米管上填充类骨磷灰石可大大提高其生物活性.A vertically aligned TiO2 nanotube array was fabricated on the surface of titanium substrate in fluoridecontaining electrolyes by anodization.Alternative Loop Immersion Method（ALIM） was investigated to fill TiO2 nanotubes with the biological apatite in the saturated solution of Ca（OH）2 and 0.02 mol/L（NH4）2HPO4.In this way,the structure of the apatite-coating on the Ti substrate was changed for solving the problem of coating shedding well.And the amount of synthetic apatite formed by ALIM was quantified according to key tube properties such as the tube diameter, the layer thickness,the crystal structure（amorphous or anatase）,etc.The effect of filling biological apatite of TiO2 nanotubes fabricated in glycerol-based electrolyte at 60V is the best.And the rate of inducing biological apatite on amorphous TiO2 nanotubes with the treatment of ALIM is better than that of anatase TiO2 nanotubes.Mineralization in vitro experiments indicates that TiO2 nanotubes after ALIM treatment promote natural apatite formation significantly in a simulated body fluid（SBF）.Such TiO2 nanotube arrays with ALIM treatment,are useful as a well-adhered bioactive surface layer on Ti implant metals for orthopaedic and dental implants.

关 键 词：TIO2纳米管 交替循环浸泡 填充 类骨磷灰石 

分 类 号：O646[理学—物理化学] O614[理学—化学]