自噬过程的晚期阶段  

The Late Stages of Autophagy

作　　者：杜万清[1] 俞立[1] 

机构地区：[1]清华大学生命科学学院,北京100084

出　　处：《中国细胞生物学学报》2011年第1期1-7,共7页Chinese Journal of Cell Biology

摘　　要：自噬是高度保守的细胞内降解途径。在此过程中,部分细胞质和细胞器被双层膜的囊泡包裹形成自噬体,随后与溶酶体融合并降解被吞噬的物质。降解产物被释放到细胞质中重新用于必需的物质和能量合成。本文主要关注自噬的晚期阶段,即从自噬体合成结束到溶酶体再生过程。通过对这一过程相关基因及蛋白产物的研究,初步揭示了此过程的分子机制。Autophagy is highly conserved degradation process in which portions of cytosol and organelles are sequestered into a double-membrane vesicle,an autophagosome,and delivered into a degradative organelle,the vacuole/lysosome,for breakdown and eventual recycling of the resulting macromolecules.In this review,we discussed the late stages of autophagy,such as fusion of autophagosome with lysosome/vacuole,degradation of autophagosome and reformation of lysosome from hybrids.Identification of many autophagy-related genes reveals the machinery of the late stages of autophagy.Here,we summarize current information about the molecular mechanism of this process initially.

关 键 词：自噬 晚期阶段 融合 

分 类 号：Q25[生物学—细胞生物学]