舒洛地特对糖尿病肾病白蛋白尿的影响研究  

Study of the effect of Chulo on albuminuria in diabetic nephropathy

作　　者：张洪波[1] 康萍[1] 李吉河[1] 杜鹃[1] 孙薇[1] 谢长英[1] 于莉[1] 

机构地区：[1]大庆油田总医院,黑龙江大庆163001

出　　处：《现代中西医结合杂志》2011年第4期405-406,416,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察舒洛地特(伟素)对糖尿病肾病白蛋白尿的影响。方法将52例伴有微量白蛋白尿及大量蛋白尿的糖尿病患者随机分为2组,2组均给予常规治疗,治疗组同时给予伟素200 mg/d口服,2组疗程均为4个月,每2个月监测1次24 h尿蛋白定量、尿白蛋白排泄率,在停药后4个月随访。结果治疗组24 h尿蛋白定量、尿白蛋白排泄率较治疗前明显下降(P均<0.01),而且在停药后4个月内患者24 h尿蛋白定量及尿蛋白排泄率仍在持续下降,治疗组与对照组相比有显著性差异(P均<0.05)。结论舒洛地特能有效改善糖尿病肾病患者白蛋白尿,延缓糖尿病肾病的进展。Objective It is to observe the effect of Chulo to on albuminuria in diabetic nephropathy.Methods 52 cases of patients with diabetes complicating with microalbuminuria and much proteinuria were randomly divided into two groups： both were treated with normal method,and the treatment group was given Chulo 200 mg/d by oral use.Both the treatment courses were for 4 months.24 h urinary protein and urinary albumin excretion rate were detected once every two months.The patients were followed up in 4 months after stopping treament.Results The 24-hour urinary protein,urinary albumin excretion rate in the treatment group was significantly lower than that before treatment（P〈0.01）,furthermore,they still kept decreasing within 4 months after stopping treatment（P〈0.05）.There was significant difference in the indexes between treatment group and control group（P〈0.05）.Conclusion Chulo can effectively improve diabetic nephropathy albuminuria,and delay the progress of diabetic nephropathy.

关 键 词：舒洛地特 糖尿病肾病 白蛋白尿 

分 类 号：R587.2[医药卫生—内分泌]