SPA-1通过Rap1信号通路参与疾病的发生和发展  

Rap1 Signalling Pathway of SPA-1

作　　者：李敏[1] 冯爱平[1] 苏莉[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤科,武汉430022 [2]华中科技大学生命科学院,武汉430022

出　　处：《医学综述》2011年第2期198-201,共4页Medical Recapitulate

摘　　要：SPA-1为一种小分子蛋白酶激活蛋白,目前在细胞及肿瘤中研究较多。在细胞中,SPA-1通过与不同的分子或者蛋白相互作用,影响Rap1三磷酸鸟苷酶活性,从而参与细胞功能的调节。在肿瘤方面,SPA-1在乳腺癌和白血病中的研究较多,大量临床研究发现SPA-1与乳腺癌有重要联系,而动物实验发现SPA-1与白血病有关,还发现SPA-1-/-的小鼠部分发生了狼疮样肾小球肾炎,猜测SPA-1在自身免疫疾病中起一定作用。但SPA-1在这些疾病中具体作用机制尚在进一步探索之中。SPA-1 is a small GTPase-activating protein,mainly studied in cells and tumors at present.In cells,SPA-1 participates in the regulation of cell functions through interacting with different molecules or proteins,promoting Rap1 GTPase activity;SPA-1 also plays an important role in tumor and leukemia.It is involved in breast cancer as documented by extensive clinical studies,as well as leukemia in animal experiments.Mice that are SPA-1deficient develop autoimmune diseases.However,the specific role of SPA-1 in the mechanism of these diseases is still under further exploration.

关 键 词：SPA-1 Rap1 白血病 乳腺癌 自身免疫性疾病 

分 类 号：R392.11[医药卫生—免疫学]