糖尿病患者早期肾损伤的诊断进展  

Research Progress of Early Diagnosis in Diabetic Renal Injury

作　　者：肖文霞[1] 陈小燕[1] 

机构地区：[1]广州医学院第一附属医院内分泌科,广州510120

出　　处：《医学综述》2011年第2期272-275,共4页Medical Recapitulate

基　　金：广东省自然科学基金(07301662)

摘　　要：糖尿病肾病的主要临床特点是尿白蛋白排泄率和肾小球滤过率异常增高并伴随肾脏结构的改变。目前诊断糖尿病肾病的金标准——尿微量白蛋白定量检测,一定程度反映了肾脏损害,但并不能准确地反映肾功能的变化趋势。近年来,各种更为早期、稳定、准确的诊断技术,包括血/尿生化指标,如半胱氨酸蛋白酶抑制剂C、β2微球蛋白、N-乙酰β-氨基葡萄糖苷酶等;无创的肾脏影像学检查,如磁共振弥散加权成像、动脉血氧水平依赖功能磁共振成像等逐渐成为研究的热点。探索糖尿病早期肾损害的诊断进展,对早期防治具有重要意义。The main clinical features of iabetic nephropathy is abnormal increasing of the urinary albumin excretion rate and glomerular filtration rate,accompanied by changes in kidney′s structure.The current gold standard for diagnosis of diabetic nephropathy is microalbuminuria.But it couldn′t reflect the trend of renal function more early and accurately.In recent years,more early,stable and accurate diagnositc techniques,including blood/urine biochemical indicators,such as cystatin C,β2-microglobulin,N-acetyl-β-D-glu-co-aminidase etc.Non-invasive imaging examination of kidney are also becoming hotspots,such as diffusion weighted imaging,blood oxygen level-dependent magnetic resonance imaging etc.To explore the diagnosis of early diabetic renal injury is important for early prevention.

关 键 词：糖尿病 肾损害 早期诊断 

分 类 号：R587.1[医药卫生—内分泌]