膀胱移行细胞癌中14-3-3σ和CyclinB1表达的临床意义  

The Expression and Significance of 14-3-3σ and CyclinB1 in Bladder Transitional Cell Carcinomas

作　　者：宋洪斌[1] 吴奎[1] 张旗[1] 田超[1] 

机构地区：[1]安徽医科大学附属省立医院泌尿外科,合肥230001

出　　处：《医学综述》2011年第2期303-305,共3页Medical Recapitulate

摘　　要：目的探讨14-3-3σ和细胞周期蛋白B1(CyclinB1)在膀胱移行细胞癌组织中的表达与膀胱移行细胞癌生物学行为的关系。方法用免疫组化S-P方法检测10例正常膀胱组织,48例膀胱移行细胞癌患者肿瘤组织中14-3-3σ和CyclinB1的表达;分析14-3-3σ和CyclinB1的表达与膀胱移行细胞癌分期、分级、术后生存率的相关性及14-3-3σ和CyclinB1在膀胱移行细胞癌组织中表达的相关性。结果正常对照组10例14-3-3σ中9例阳性(90%),膀胱移行细胞癌组48例14-3-3σ8例阳性(16.6%);正常对照组中CyclinB1 2例阳性(20%),而膀胱移行细胞癌组48例CyclinB1 38例阳性(79.2%)。结论 14-3-3σ低表达和CyclinB1的高表达与膀胱移行细胞癌分级、病理分期显著相关;14-3-3σ高表达和CyclinB1低表达可抑制膀胱移行细胞癌的发生。二者的协同作用可能促进肿瘤的演进,检测14-3-3σ和CyclinB1可作为评价膀胱移行细胞癌的新的参考指标。Objective To investigate the role of 14-3-3σand CyclinB1 in the occurrence and development of bladder transitional cell carcinoma.Methods S-P method was applied to study the expression of 14-3-3σand CyclinB1 proteins in 10 normal bladder and 48 bladder cancer,according to clinical results,to analize the prognosis value of 14-3-3σand CyclinB1 proteins in bladder cancer.Results The expression rate of 14-3-3 σwas 90%in the normal bladder but 16.6% in the bladder cancer,and CyclinB1 was 20%in the normal bladder but 79.2% in the bladder cancer.Both 14-3-3σand CyclinB1 expression were related to histological grade and pathological stage of tumors,closely.Conclusion The excessive lower expression of 14-3-3σand higher expression of CyclinB1 play an important role in the bladder cancer.The expression of 14-3-3σand CyclinB1 may be as a reference marker in the prognosis of bladder cancer.

关 键 词：膀胱移行细胞癌 14-3-3σ CYCLINB1 免疫组织化学 

分 类 号：R694[医药卫生—泌尿科学]