静脉注射人脑利钠肽对急性失代偿性心力衰竭心率变异性的作用  

Effects of recombinant human brain natriuretic peptide on heart rate variability in patients with acute decompensated heart failure

作　　者：孙家安[1] 张文彦[2] 曹彦敏[3] 张洁芳[3] 

机构地区：[1]中国人民解放军白求恩国际和平医院心内科,石家庄市050081 [2]河北省卫生厅卫生监督局 [3]河北省石家庄市第四医院内科

出　　处：《河北医药》2011年第4期491-492,共2页Hebei Medical Journal

摘　　要：目的观察分析重组人脑利钠肽(rh-BNP)治疗急性失代偿心力衰竭(ADHF)对心率变异性(HRV)的影响。方法选择28例ADHF患者,采用1.5～2.0μg/kg负荷剂量静脉推注rh-BNP,随后按0.0075～0.0150μg·kg-1·min-1维持剂量进行微量泵静脉内注射24h。治疗前后均行24h动态心电图监测检查,对rh-BNP治疗前后进行心率功率谱时域和频域分析。结果 rh-BNP治疗后HRV值较对照组显著改善,其中时域指标:全部正常R-R间期的标准差(SDNN)、每5分钟R-R间期均值的标准差(SDANN)、正常相邻R-R间期差值的均方根(RMSSD)、正常相邻R-R间期差值>50ms的百分比(PNN50)、心率均显著改善(P<0.01),频域指标:总频谱(TF)、低频(LF)和高频(HF)亦明显改善(P<0.01)。结论 rh-BNP可改善ADHF患者的HRV。Objective To investigate the effect of recombinant human brain natriuretic peptide（rh-BNP） on heart rate variability in patients with acute decompensated heart failure（ADHF）.Methods 28 patients with ADHF,based on the routine therapy,were treated with rh-BNP for 24 hours.The heart rate power spectral density and time-domain were analyzed,with 24 hour electrocardiographic monitoring before and after using rh-BNP.Results As compared with that in control group,the time-domain analysis in rh-BNP after the treatment revealed a significant improvement in SDNN,SDANN,RMSSD,PNN50（P〈0.01）.Heart rate and frequency domain analysis showed there was a obvious improvement of total,low and high frequency components（P〈0.01）.Conclusion The rh-BNP can significantly improve the heart rate variability in patients with ADHF.

关 键 词：重组人脑利钠肽 心力衰竭 急性失代偿性 心率变异性 

分 类 号：R541.6[医药卫生—心血管疾病]