黄麦合剂治疗脾肾阳虚少和弱精症33例  

Thirty-three Cases of Oligoathenospermia Due to Spleen and Kidney Yang Deficiency and Male Infertility Treating with Huangmai Mixture

作　　者：王鸿祥[1] 陈斌[1] 胡凯[1] 金炎[1] 韩银发[1] 姚晓东[2] 沈金芳[2] 王益鑫[1] 黄翼然[1] 

机构地区：[1]上海交通大学医学院附属仁济医院泌尿外科、上海市男科学研究所,200001 [2]上海交通大学医学院附属仁济医院药剂科,200001

出　　处：《医药导报》2011年第1期24-28,共5页Herald of Medicine

基　　金：上海申康医院发展中心市级医院中医药验方临床评价项目(基金编号:SHDC12007414);上海市人口和计划生育委员会科研基金(基金编号:2010JG03);上海市科委国际合作项目,男性生殖的基础与应用研究(基金编号:08410701700)

摘　　要：目的探讨黄麦合剂治疗男性脾肾阳虚少、弱精症的疗效。方法将泌尿男科门诊66例不育症患者随机分为治疗组与对照组,每组33例。治疗组给予黄麦合剂,每次20mL,tid,po;对照组给予复方玄驹胶囊(每粒0.42g),每次2粒,tid,餐前15～30min,po。治疗24周,并分别于治疗第4,8,12,16,20,24周末复诊,接受访视,并做各项检查及安全性评估。观察指标包括:精液常规分析、精子形态学分析、精液抗精子抗体、精浆生化检查、性激素5项测定等。结果治疗24周后,治疗组和对照组精子密度、a级精子比例、a+b精子比例及活率均较用药前提高,差异有统计学意义(P<0.05)。两组共有6例患者在治疗期间配偶怀孕(治疗组4例,对照组2例)。两组总有效率分别为63.33%和53.33%,差异无统计学意义(P>0.05)。两组精浆果糖密度和α-中性糖苷酶均有所提高,两组提高百分比差异无统计学意义(P>0.05)。两组性激素指标治疗前后均变化不大(P>0.05)。结论黄麦合剂治疗脾肾阳虚少、弱精症,与复方玄驹胶囊有基本相同的疗效和安全性,且价格相对低廉,适合临床推广应用。Objective To investigate the efficacy of huangmai mixture treating oligoathenospermia due to spleen and kidney yang deficiency.Methods Sixty-six male infertility patients were randomized into experimental group and control group,given with huangmai mixture and compound xuanju capsule,respectively.All patients recruited went through a treating period of 24 weeks and came for follow-up visits at the 4th,8th,12th,16th,20th and 24th weekend,receiving clinical examinations and safety evaluation.Observation items included semen analysis,sperm morphology analysis,antisperm antibody,seminal plasma biochemical analysis and serum sex hormone.Results After treatment for 24 weeks,the total effective rates of experimental group and control group were 63.33% and 53.33%,respectively.The total effective rates between groups were not statistically significant（P0.05）.In total,6 patients＇ partners conceived during treating period（4 in experimental group and 2 in control group）.Compared with those before treatment,the sperm density,sperm motility,a class sperm percentage,a＋b class sperm percentage and sperm activity in the treated group and control group increased significantly（P0.05）.Fructose density and α-glycosidase also increased,but the increasing degree showed no statistical significance.Serum sex hormone of two groups did not vary before and after treatment（P0.05）.Statistical significance was not observed in percentage increased between groups（P0.01）.Conclusion Huangmai mixture for treating oligoathenospermia due to spleen and kidney yang deficiency has the same efficacy and safety compared with compound xuanju capsule,with a relatively low cost,huangmai mixture is more suitable for clinical application.

关 键 词：黄麦合剂 玄驹胶囊 复方 不育症 脾肾阳虚 

分 类 号：R286[医药卫生—中药学] R697[医药卫生—中医学]