异氟烷对大鼠肝缺血再灌注肺组织损伤的保护作用研究  

Protective effects of Isoflurane on lung injury from hepatic ischemia-reperfusion in rats

作　　者：盖毅文[1] 来炳祺 成少利 郭雄 

机构地区：[1]西安交通大学医学院第一附属医院麻醉科,西安710061 [2]陕西省肿瘤医院麻醉科 [3]西安交通大医学院

出　　处：《陕西医学杂志》2011年第1期15-17,共3页Shaanxi Medical Journal

基　　金：陕西省社发攻关基金资助(No2006K12-G5(3))

摘　　要：目的:探讨异氟烷对大鼠肝缺血再灌注后肺损伤的保护作用。方法:将20只SD大鼠随机分为两组,每组10只。两组均用氯胺酮(1m g/kg)基础麻醉。对照组进行假手术,吸入组应用异氟烷持续吸入维持麻醉后进行手术,肝脏缺血再灌注后取肺脏灌洗液以及肺组织标本。测定NF-κB的含量以及肺组织形态学观察。结果:异氟烷对实验动物维持麻醉,可以有效地降低肺组织以及肺泡灌洗液中NF-κB的含量,肺组织损伤性变化减轻。结论:异氟烷对大鼠肝缺血再灌注肺组织损伤具有明显的保护作用。Objective： To study the protective effects of Isoflurane on lung injury from hepatic ischemia-reperfusion in rats.Methods： 20 rats were randomly divided into two groups with 10 rats each group.The two groups were performed basic anesthesia with ketamine（1mg/kg）.sham surgery for control group,while experimental group were inhalationally anesthetized with Isoflurane to maintain anesthesia during surgery in the same time.In two groups after hepatic ischemia-reperfusion,lung lavage fluid and lung tissue were sampled.Observed morphological changes of the lung tissues and determined NF-κB in lung tissue and lavage fluid.Results： Isoflurane anesthesia during hepatic ischemia-reperfusion in rats was effective in reducing NF-κB in lung tissue and lavage fluid,and lung tissue damage became attenuated.Conclusion：Isoflurane was effective to lung injury from hepatic ischemia-reperfusion in rats. KEY WORKS Repefusion injury/drug effective Oxygen compound/therapeutic use Ketamine/ therapeutic use Models,animal Rats

关 键 词：再灌注损伤/药物作用 氧化合物/治疗应用 氯胺酮/治疗应用 模型 动物 大鼠 

分 类 号：R614.2[医药卫生—麻醉学]