叶酸对女性冠心病患者血清同型半胱氨酸水平的影响  

The effects of additional use of folic acid on serum homocysteic acid level in female coronary atherosclerotic patients

作　　者：高爱宝 余星燕 冯金华[1] 

机构地区：[1]陕西省延安市人民医院心血管中心内科,延安716000 [2]广东省东莞市任康医院内科

出　　处：《陕西医学杂志》2011年第1期65-67,共3页Shaanxi Medical Journal

摘　　要：目的:探讨叶酸对女性冠心病伴高同型半胱氨酸(Hcy)血症患者的血清Hcy水平的影响。方法:对女性冠心病患者49例和正常对照组女性50例,采用荧光标记免疫检测法测定空腹血清Hcy水平,Hcy≥15μmol/L为高Hcy血症,将42例高Hcy血症女性冠心病患者随机分为对照组(20例,仅服用硝酸酯类、他汀类及肠溶阿司匹林等基础药物)和治疗组(22例,除基础用药外加用叶酸5mg口服每日3次),治疗前及治疗4周后测定患者空腹血清Hcy水平。结果:女性冠心病组患者血清Hcy水平(16.97±3.21μmol/L)明显高于正常对照组(11.21±2.92μmol/L,P<0.01)。治疗组患者治疗4周后Hcy水平为10.34±5.63μmol/L,平均降低了36.4%,治疗前、后Hcy水平有极显著性差异(P<0.01)。结论:女性冠心病患者Hcy水平较高,补充叶酸可明显降低女性冠心病高Hcy血症患者的血浆Hcy水平,改善血管内皮功能。Objective： To explore the effects of administration of additional dose of folic acid on serum homocysteic acid level of female coronary atherosclerotic patients in Yan＇an,northwest Shanxi.Methods： 49 female patients with coronary heart disease and 50 normal controls were selected into the study.Of which 42 patients with high serum Hcy level（Hcy 15μmol/L） were randomly divided into two therapeutic groups of which treated,respectively with conventional drugs such as aspirin,clopidogrel,stantins and conventional drugs plus additional use of folic acid.Results： The serum Hcy level of the female coronary patients is extremely high compared with that in normal controls（P0.01）. Treated for 4 weeks the serum Hcy level of the therapeutic groups dicresed by 36.4%.The difference between the therapeutic group with the normal controls was very distinguished.（P0.01） Conclusion： The serum Hcy level of the female coronary patients are quite higher,but given additional use of folic acid for 4 weeks later the serum Hcy levels of the patients decreased very significantly so as to function as the protection of the endotheliua of blood vessels of the body.

关 键 词：冠状动脉疾病/诊断 冠状动脉疾病/治疗叶酸/治疗应用 半胱氨酸/代谢 女(雌)性 

分 类 号：R541.4[医药卫生—心血管疾病]