1,6-二氯二苯并-对-二噁英的合成与表征  

Synthesis and characterization of 1,6-dichloro-dibenzyl para-dioxin

作　　者：李敬[1] 张学良[1] 郝双红[1] 孙家隆[1] 

机构地区：[1]青岛农业大学化学与药学院,山东青岛266109

出　　处：《化学研究》2011年第1期29-31,共3页Chemical Research

基　　金：青岛市科技计划项目(06-3-2-4-nsh)

摘　　要：二噁英是一类毒性极大的特殊脂溶性有机化合物,严重污染环境和危害人类健康.1,6-二氯二苯并-对-二噁英是一种二噁英的前驱体,常作为杂质存在于某些农药产品中,在农药使用前需检测其含量.为此,采用磺酰氯氯化邻苯二酚得到中间产物4-氯邻苯二酚,再将中间产物与2,6-二氯硝基苯反应得到1,6-二氯二苯并-对-二噁英.利用高效液相色谱分析了产物的纯度,并通过气相色谱、核磁共振谱(1H NMR和13C NMR)对合成的目标物进行了表征.结果表明,目标产物柱层析品的纯度为99.76%.As a kind of special fat-soluble organic compounds with high toxicity,dioxin is severely harmful to environment and human health.Besides,1,6-dichloro-dibenzyl para-dioxin as a precursor of dioxin often exists in some pesticides,and its content in pesticides usually needs to be monitored before putting into use.Thus pyrocatechol was chlorinated with sulfonyl chloride yielding intermediate 4-chloro-pyrocatechol;then 4-chloro-pyrocatechol was allowed to react with 2,6-dichloro-nitrobenzene to give the title compound.The purity of the recrystallized final product was determined by means of high performance liquid chromatography and its structure was confirmed by nuclear magnetic resonance（1H NMR and 13C NMR） spectroscopy.Results indicate that the target product has a purity of 99.76%.

关 键 词：二噁英 1 6-二氯二苯并-对-二噁英 合成 表征 

分 类 号：TQ460.31[化学工程—制药化工]