硫普罗宁对合并乙型肝炎的肺结核患者抗结核药物治疗时保肝作用的观察  

Clinical efficacy of tioprouln in protecting liver function in tuberculous patients concomitant with hepatitis B

作　　者：张雪峰[1] 邹公民[1] 覃兆科[2] 杨琴[1] 

机构地区：[1]湖北省荆州市第二人民医院药剂科,434000 [2]湖北省荆州市第二人民医院感染科,434000

出　　处：《中国医药》2011年第2期185-186,共2页China Medicine

摘　　要：目的 研究硫普罗宁治疗乙型肝炎病毒标志物阳性肺结核患者短程化疗中对肝脏的保护和治疗作用.方法 收集我院收治的乙型肝炎病毒标志物阳性肺结核患者640例,按住院号分为治疗组330例和对照组310例.2组均采用相同的肺结核化疗方案,治疗组在强化阶段加服硫普罗宁100 mg,3次/d.定期复查2组患者肝功能变化,并观察其临床症状.结果 治疗组有70例（21.2%）ALT升高,且为一过性,无一例停止化疗;对照组有150例（48.4%）ALT升高,6例出现黄疸,8例中断治疗.2组ALT升高程度及肝损害程度差异具有统计学意义（P＜0.05）.治疗组发热、咳嗽、盗汗平均消退时间分别为（10.0±4.6）、（10.8±5.2）及（12.4±7.0）d;对照组分别为（12.8±4.0）、（12.6±4.4）、（16.2±6.4）d.2组差异有统计学意义,P＜0.01.结论 硫普罗宁能减轻化疗中出现的肝脏不良反应,保护肝功能,改善结核中毒症状,对结核患者短程化疗具有积极的辅助治疗意义.Objective To study the proctective effect of liver function with tiopronin in tuberculousis patients with hepatitis B. Methods Pulmonary tuberculosis patients with hepatatis B were randomly divided into 2 groups： tiopronin treatment group and normal treatment group. Two groups were given short-course anti-tuberculous treatment. The abnormalisise of hepatic function,clinical manifestations and the onset time of abnormalisise of hepatic function and clinical manifestations were compared and analyzed. Results There was a significant improvement in the abnormalisise of hepatic function and clinical manifestations in tiopronin treatment group （P 〈 0.05）.Conclusions Tiopronin can reduce the liver adverse reactions,protect liver funtions and improve the toxic symptoms. It will play a positive role in adjuvant therapy of short-couse chemotherapy of pulmonary tuberculousis patients with hepatitis B.

关 键 词：硫普罗宁 结核 肺 肝炎病毒 乙型 丙氨酸转氨酶 

分 类 号：R521[医药卫生—内科学]