哌拉西林舒巴坦钠与苄星青霉素联合治疗一、二期梅毒的疗效及不良反应评价  

Evaluation on the Curative Effect and Side Effect of the Combined Treatment with Piperacillin Sulbactam Sodium and Benzathine Penicillin on Primary Syphilis and Secondary Syphilis

作　　者：张伟[1] 叶光荣[1] 赵丹[1] 

机构地区：[1]攀枝花市第四人民医院皮肤性病科,四川617061

出　　处：《西南军医》2011年第1期8-10,共3页Journal of Military Surgeon in Southwest China

摘　　要：目的评价哌拉西林舒巴坦钠与苄星青霉素联合治疗一、二期梅毒患者的疗效及不良反应。方法回顾性分析我院2008年12月～2009年10月收治的72例一、二期梅毒患者的临床资料,所有患者随机分为治疗组和对照组各36例,治疗组采用哌拉西林舒巴坦钠与苄星青霉素联合治疗,对照组仅采用苄星青霉素治疗,比较分析两组患者的临床疗效及不良反应发生情况。结果 治疗组的痊愈率为83.3%,明显高于对照组的61.1%,两组间有显著性差异(P<0.05);治疗组的不良反应发生率为8.3%,略低于对照组的13.9%,两组间无显著性差异(P>0.05)。结论 哌拉西林舒巴坦钠与苄星青霉素联合治疗一、二期梅毒患者获得较佳疗效,且不良反应少,值得临床推广应用。Objective To evaluate the curative effect and side effect of the combined treatment with piperacillin sulbactam sodium and benzathine penicillin on primary and secondary syphilis.Methods A retrospective analysis was made to the clinical data of 72 cases with primary or secondary syphilis;they were randomly divided into 2 groups： treatment group and control group,36 cases in each;the combined treatment with piperacillin sulbactam sodium and benzathine penicillin was given to patients in treatment group while only benzathine penicillin was given to patients in control group;a comparative study was made to the curative effects and side effects between the 2 groups.Result The curative rate of treatment group was 83.3%,much higher than that of control group（61.1%）,the difference between the 2 groups was significant（P0.05）;the occurrence of side effect of treatment group was 8.3%,a little lower than that of control group（13.9%）,the difference between the 2 groups was of no significance（P0.05）.Conclusions The combined treatment with piperacillin sulbactam sodium and benzathine penicillin is of better curative effect and less side effect on primary and secondary syphilis;it is worthy of wide application in clinic.

关 键 词：梅毒 早期 哌拉西林舒巴坦钠 苄星青霉素 疗效 不良反应 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]