甲氨蝶呤、环孢素与维A酯治疗中重度银屑病效果的系统评价  

Efficacy and safety of cyclosporine,methotrexate and etretinate in psoriasis:systematic review

作　　者：王媛[1] 张悦[1] 程岩峰[1] 韩秀萍[1] 

机构地区：[1]中国医科大学附属盛京医院皮肤科,辽宁沈阳110004

出　　处：《中国误诊学杂志》2011年第1期12-14,共3页Chinese Journal of Misdiagnostics

摘　　要：目的比较甲氨蝶呤、环孢素、维A酯治疗银屑病的有效性和安全性。方法搜索中英文数据库,收集所有与甲氨蝶呤、环孢素及维A酯类药物治疗银屑病有关文献。按照纳入和排除标准筛选。采用Cochrane协作网的RevMAN4.2软件进行统计分析。结果纳入文献8篇,包括584例患者。比较治疗后的PASI均值,基本痊愈人数、有效率及不良反应等相关指标的原始数据。结论甲氨蝶呤与环孢素疗效比较差异无统计学意义,环孢素优于维A酯。不良反应比较,三种药物均无严重和不可逆的不良反应发生。Objective To study and compare the efficacy and safety of cyclosporine、methotrexate and etretinate in the treatment of psoriasis by systematic review.Method According to the inclusion and exclusion standards,Chinese and English database were searched to collect the articles related to cyclosporine、methotrexate and etretinate in the treatment of psoriasis.The data was statistically compared by software RevMAN4.2.Result 8 RCT articles were enlisted,including 584 cases.PASI score、remission rate、effective rate and adverse effects were studied in all the 8 RCT articles.Conclusion The efficacy of cyclosporine and methotrexate was similar（P0.05）;Cyclosporine was more effective than etretinate（P0.05）.There was no severe irreversible adverse effects during the treatments.

关 键 词：银屑病/药物疗法 甲氨蝶呤/治疗应用 环孢菌素/治疗应用 阿维A酯/治疗应用 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]