应用ROC曲线评价GPI、抗CCP抗体及RF在类风湿性关节炎中的诊断价值  

The Diagnostic Value of Serum GPI,Anti-CCP and RF in Patients with Rheumatoid Arthritis

作　　者：国霞[1] 栾清欣[1] 刘丰海[1] 

机构地区：[1]山东青岛市市立医院检验科,266011

出　　处：《医学理论与实践》2011年第1期20-22,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨血清中葡萄糖-6-磷酸异构酶(GPI)、抗环胍氨酸肽抗体(抗CCP抗体)及类风湿因子(RF)对类风湿性关节炎(RA)的诊断价值。方法:采用酶联免疫吸附试验(ELISA)检测137例RA患者、141例其他风湿病患者和60例健康对照者血清GPI、抗CCP抗体及RF浓度,通过ROC曲线分析和逐步Logistic回归结果的ROC曲线下面积(AUC),对3个指标单独及联合检测的特异性进行比较分析。结果:3个指标在RA患者的浓度显著高于其他风湿性疾病组和健康对照组(P<0.01);在RA活动组和RA非活动组中亦有明显差异(P<0.01);逐步Logistic回归法模拟变量的AUC高于单一指标的AUC,3个指标联合检测的特异性最高。结论:GPI可作为诊断RA及判断其疾病活动性的一个新指标,运用Logistic回归和ROC曲线综合分析可提高RA诊断的准确性。Objective：To explore the differential diagnostic value of glucose-6-phosphate isomerase（GPI）,Anti-cyclic citrullinated peptides antibodies and rheumatoid factor with ROC curve in patients with rheumatoid arthritis（RA）.Methods：The levels of serum GPI in 137 patients with RA,141 patients with inflammatory diseases and 60 normal control group were tested by ELISA.The area under the ROC curve（AUC） of three factors and stepwise LR results were compared by specificity.Results：The levels of three tested markers in patients with rheumatoid arthritis were higher than that in other inflammatory diseases and in normal control group（P0.01）,Active RA and inactive RA were also have significant statistical differences（P0.01）,The AUC from stepwise logistic regression was larger than the AUC of three factors respectively.The presence of the combinational test for three factors was the highest.Conclusion：The GPI could be a new marker for diagnosing RA and accessing its activity.Application of Logistic regression and ROC curve increase diagnostic accuracy in RA.

关 键 词：ROC曲线 GPI 关节炎 类风湿 抗CCP抗体 RF 

分 类 号：R446.6[医药卫生—诊断学]