微量喂养对喂养不耐受早产儿血清胃泌素水平的影响  

Effect of Minimal Feeding on Levels of Serum Gastrin in Premature Infants with Feeding Intolerance

作　　者：许东宝[1] 汪浩文[1] 黄金保[2] 祝选姣[1] 黄玮[1] 胡海英[1] 

机构地区：[1]皖南医学院附属池州医院(池州市人民医院)新生儿科,247100 [2]皖南医学院附属池州医院(池州市人民医院)检验科,247100

出　　处：《中华全科医学》2011年第2期183-184,共2页Chinese Journal of General Practice

基　　金：安徽省池州市科技计划项目(ZC09010)

摘　　要：目的探讨微量喂养对早产儿血清胃泌素(gastrin,GAS)水平的影响及其对早产儿喂养不耐受的治疗作用。方法将42例早产儿分为观察组(有喂养不耐受)22例与对照组(无喂养不耐受)20例,观察组患儿予微量喂养;对照组患儿行常规喂养。两组患儿分别在生后24 h内及7日龄后行血清胃泌素水平的测定,观察两组患儿治疗1周后临床状况改善情况。结果观察组在入院时的血清胃泌素水平较对照组显著减低,治疗7 d后两组血清胃泌素水平无显著差异;观察组在达全量肠内营养时间、恢复至出生体重时间较对照组显著延长(P<0.05,P<0.01),而在住院期间血清总胆红素水平高峰值方面差异无统计学意义(P>0.05)。两组患儿均未发生一例坏死性小肠结肠炎、吸入性肺炎等严重的喂养并发症。结论早产儿血清GAS水平与胃肠功能紊乱的发生关系密切,微量喂养可促进早产儿胃肠道发育成熟。Objective To explore the effect of the minimal feeding on the level of serum gastrin（GAS） in premature infants with feeding intolerance. Methods Forty two cases of the premature infants were divided into the two groups. The observe group （22 cases with feeding !ntolerance） were given by the minimal feeding, and the control group（ 20 cases ） were given the routine feed. The serum gastrin of two groups was detected in 24 h and after 7 days, respectively ; and was observed in clinical condition improved treatment after a week. Results The levels of the serum GAS in the observe group were significantly lower in 24h than those in the control group（ P 〈 0.05 ）, but the different between the two groups after 7 days was not significant （P 〉 0.05 ）. The time to establish complete enteral nutrition and days to regain birth weight in the observe group were significantly longer than those in the control group. However, there was no significant difference between the two groups in the horizontal peak value of total bilirubin of serum. None of the two groups had the severe complications such as necrotized enterocolitis and inhalation pneumonia. Conclusion The levels of serum GAS is closely related to the emergence of the function disorder of gastrointestinal tract. The minimal feeding can promote the development of the gastrointestinal system.

关 键 词：婴儿 早产儿 微量喂养 胃泌素 

分 类 号：R722.6[医药卫生—儿科]