羟丙基-β-环糊精-芒果苷包合物在小鼠体内的药代动力学研究  

Study on Pharmacokinetics of HP-β-CD-Mangiferin in Mice

作　　者：李杰[1] 周慧[1] 郑一敏[1] 曾品涛[1] 王琳琳[1] 胥秀英[1] 傅善权[1] 

机构地区：[1]重庆理工大学药学与生物工程学院,重庆400050

出　　处：《中国药业》2011年第2期24-25,共2页China Pharmaceuticals

摘　　要：目的建立测定小鼠血浆中羟丙基-β-环糊精-芒果苷包合物质量浓度的高效液相色谱(HPLC)法,并用于药代动力学研究。方法小鼠一次性灌胃给予3.0 g/kg羟丙基-β-环糊精-芒果苷包合物后,用HPLC法检测不同时间间隔的血药浓度,计算药代动力学参数。结果小鼠一次性灌胃给予羟丙基-β-环糊精-芒果苷包合物后,分布相半衰期(t1/2α)为(8.226±0.972)h,消除相半衰期(t1/2β)为(8.674±1.112)h,药时曲线下面积(AUC)为(3.058±0.836)μg.h/kg。结论 HPLC法简便、可靠,可用于芒果苷包合物药代动力学研究,小鼠体内药代动力学过程符合二房室开放模型。Objective To establish a HPLC method for the determination of hydroxypropyl（HP）-β-cyclodextrin（CD）-mangiferin in mice and to investigate its pharmacokinetics.Methods After administration of 3.0 g/kg inclusion compound of HP-β-CD-mangiferin by gavage for once in mice,the serum concentrations at differential time intervals were determined by RP-HPLC.The compartment model was calculated with 3P97 software.Results t1/2αwas（8.226±0.972）h,t1/2βwas（8.674±1.112）h and AUC was（3.058±0.836） μg·h/kg in mice after once gavage administration of HP-β-CD-mangiferin inclusion compound.Conclusion The HPLC method is simple and reliable,which can be applied to the pharmacokinetic study.The kinetics process of HP-β-CD-mangiferin is fitted to two-compartment model in mice.

关 键 词：芒果苷 包合物 高效液相色谱法 药代动力学 

分 类 号：R285.5[医药卫生—中药学] R282.71[医药卫生—中医学]