金不换总生物碱治疗大鼠慢性萎缩性胃炎的实验研究  

Experimental Study on Total Alkaloid of Stephania delavayi Diels for Treating Rat Chronic Atrophic Gastritis

作　　者：吴丽萌[1] 赖东梅[1] 陈娟[1] 周长华[2] 马仁强[2] 陈健文[2] 

机构地区：[1]广东省深圳市宝安区人民医院,广东深圳518101 [2]中山大学药学院,广东广州510080

出　　处：《中国药业》2011年第2期27-29,共3页China Pharmaceuticals

摘　　要：目的研究金不换总生物碱对慢性胃炎的作用。方法饮用及灌胃给予20mmol/L去氧胆酸钠、30%及60%乙醇13周建立慢性萎缩性胃炎模型后,将大鼠随机分为正常对照组,模型对照组,金不换总生物碱高、中、低剂量组和三九胃泰组,观察其对胃酸酸度、胃蛋白酶活性、胃黏膜血流量和胃黏膜组织病理的影响。结果与模型对照组比较,金不换总生物碱可改善慢性萎缩性胃炎大鼠体重,明显增加胃液游离酸浓度、胃蛋白酶活性和胃黏膜血流量(P<0.05或P<0.01),并能明显减轻胃黏膜的病理学损害。结论金不换生物碱对慢性萎缩性胃炎模型大鼠胃黏膜有良好的治疗作用,为其临床应用提供了药理学依据。Objective To study the effects of total alkaloid of stephania delavayi diels on treating chronic atrophic gastritis（CAG） in rats.Methods 20 mmol/L sodium deoxycholate combined 30%,60%alcohols were given to rats for 13 weeks to establish CAG model.The rats were randomly divided into six groups：normal control group,model control group,high,medium and low doses groups with total alkaloid of stephania delavayi diels,and Sanjiu Weitain group.The acidity of gastric juice,pepsase activities and volume of blood flow in gastric mucosa were detected,and the pathologic changes of the gastric mucosa were observed by microscope.Results In total alkaloid of stephania delavayi diels treated groups,the body weight was increased（P 0.05） and the concentration of free acid was significantly increased,while pepsase activities and volume of blood flow in gastric mucosa were obviously higher than those in the control groups（P 0.05 or P 0.01）.Chronic infiltration of inflammatory cells and atrophy of glands on gastric mucosa were observed less in JB groups than in model group（P 0.05 or P 0.01）.Conclusion The total alkaloid of stephania delavayi diels has the satisfactory curative efficacy for chronic atrophic gastritis in rats,which provides the pharmacological basis for its clinical application.

关 键 词：金不换 总生物碱 慢性萎缩性胃炎 胃黏膜保护 

分 类 号：R285.5[医药卫生—中药学] R282.71[医药卫生—中医学]