抗退饮对LP性发热家兔的下丘脑cAMP含量及脑腹中隔区AVP含量的影响  

The effect of anti-virus defervescent decoction on cAMP content of hypothalamus and ventral septal area of LP feverish rabbits

作　　者：马翔[1] 杨雁[1] 陈慧敏 肖玉臣 

机构地区：[1]解放军260医院,石家庄050041

出　　处：《中国病理生理杂志》1999年第8期753-755,共3页Chinese Journal of Pathophysiology

摘　　要：目的：探讨抗退饮解热机制。方法：建立家兔ＬＰ 发热模型，观察抗退饮灌胃对家兔体温的影响和用放射免疫分析法检测腹 中隔ＡＶＰ 含量及下丘脑ｃＡＭＰ 含量的变化。结果：（１） 抗退饮灌胃＋ 静注ＬＰ 组的△Ｔ 为（０－５１ ±０－２５） ℃、中隔区ＡＶＰ 含量为（１１－９５ ±４－５２） ｐｇｍｇ 、下丘脑ｃＡＭＰ 含量为（０－９１３ ±０－４５０） ｐｍｏｌｍｇ 、分别低于ＮＳ 灌胃＋ 静注ＬＰ 组的△Ｔ（１－１８ ±０－２７） ℃、中隔区ＡＶＰ 含量（２２－３７ ±３－５８） ｐｇｍｇ 、下丘脑ｃＡＭＰ 含量（１－５６２ ±０－３６０） ｐｍｏｌｍｇ（ Ｐ＜０－０１） 。（２） 中隔区ＡＶＰ 含量变化与体温变化呈明显正相关（ｒ ＝ ０－７８２ ，Ｐ＜ ０－０１） 。结论：抗退饮解热机制可能是通过抑制下丘脑ｃＡＭＰ 含量升高，同时促进腹中隔ＡＶＰAIM:To explore the mechanisms of anti-virus defervescent decoction(AVDD,KTY) decreasing leucocytic pyrogen (LP) induced fever and the normal body temperature in rabbits. METHOD:The LP-induced fever model was established in rabbits. Fever response of rabbits was observed and the arginine vasopressin (AVP) content in the ventral septal area (VSA) and cAMP content in hypothalamus (HP) were determined by radioimmunoassay following stomach infusion of AVDD.RESULTS:(1)In AVDD and LP group, the △T was(0.51±0.25)℃, AVP content in VSA was (11.95±4.52) pg/mg, cAMP content in HP was (0.91±0.45) pmol/mg. In NS and LP group, they were (1.18±0.27)℃, (22.37±3.58) pg/mg and (1.56±0.36) pmol/mg, respectively. So the result of NS and LP group was superior to that of AVDD and LP group( P <0.01). (2)The AVP content in VSA paralleled with the fluctuation of temperature ( r =0.782, P <0 01).CONCLUSION:The mechanisms of AVDD in decreasing fever were probably by inhibited the increasing of cAMP content in HP, and meanwhile promoted the releasing of AVP content in VSA.

关 键 词：发热 CAMP AVP 中医药疗法 抗退饮 家兔 

分 类 号：R255.105[医药卫生—中医内科学] R285.5[医药卫生—中医学]