空腹胰岛素以及胰岛素抵抗与良性前列腺增生症的相关性研究  

The association of fasting insuline and insuline resistance with benign prostatic hyperplasia

作　　者：孟宪琴[1] 屈晓冰[2] 杜万红[1] 刘颖[2] 刘伟[1] 

机构地区：[1]解放军第一六三医院老年病科,长沙410003 [2]中南大学湘雅二医院老年病科

出　　处：《中国综合临床》2011年第1期16-19,共4页Clinical Medicine of China

基　　金：中央保健专项资金科研课题（B2009A058）;湖南省科学技术厅科技计划项目（2009FJ3076）

摘　　要：目的 探讨空腹胰岛素（FINS）以及胰岛素抵抗（IR）对良性前列腺增生症（BPH）病程的影响,揭示FINS、IR在BPH疾病进展中的作用.方法 通过对老年病科门诊就诊的≥60岁BPH患者进行流行病学调查,对人选的117例BPH患者的FINS、胰岛素抵抗指数（HOMA-IR）进行分组,再分别采用BPH相关评价指标前列腺体积（PV）、血清前列腺特异性抗原（PSA）、国际前列腺症状评分表（IPSS）、BPH病程时间等进行统计分析和比较.结果 高胰岛素血症（HINS）BPH组前列腺体积[（56.46±26.88）ml与（44.84±17.66）ml,t=-2.420,P=0.017]、BPH病程[（18.00±6.91）年与（13.93±7.74）年,t=-2.180,P=0.031]与FINS正常的BPH组比较差异有统计学意义,IPSS、PSA在两者之间比较差异无统计学意义.胰岛素抵抗的BPH患者前列腺体积明显大于胰岛素敏感组[（54.17±25.38）ml与（42.26±14.15）ml,t=-2.960,P=0.004],且胰岛素抵抗组BPH病程更长[（16.58±7.65）年与（13.49±7.59）年,t=-2.119,P=0.036],而IPSS、PSA组间比较差异无统计学意义.结论 FINS、IR可促进BPH病程的进展,为BPH患者病情进展的危险因素.Objective To reveal the effect of fasting insuline（FINS） and insuline resistance（IR） in the process of benign prostatic hyperplasia（BPH）. Methods One hundred and seventeen outpatients（ ≥60 ys）with BPH from geriatric department were enrolled into the study. The patients were divided into groups according to their FINS and insulin resistance index （HOMA-IR）. The indices of BPH, including volume of prostate （ PV ）,prostate specific antigen（ PSA ）, international prostate symptom score （IPSS）, course of BPH were analyzed in both groups. Results The PV （ [ 56. 46 ± 26. 88 ] ml vs [ 44. 84 ± 17.66 ] ml, P = 0. 017 ） and the course （ [ 18. 00 ± 6. 91 ] years vs [ 13.93 ± 7. 74 ] years, P = 0. 031 ） were significantly greater in BPH combined hyperinsulinemias（HINS） group than the BPH with normal FINS group;but we found no significant differences in the comparisons of serum PSA level or IPSS between two groups. The PV（ [54. 17 ± 25.38 ] ml vs [42. 26 ±14. 15]ml,P =0. 004）and the course（[ 16.58 ±7. 65] years vs [13.49 ±7. 59] years,P = 0. 036） were also significantly greater in BPH combined insuline resistance gruop than the insulin sensitivity group, again we found no significant differences in the comparisons of serum PSA level or IPSS between two groups. Conclusion FINS and IR are risk factors of progressed BPH and can promote the progress of BPH.

关 键 词：良性前列腺增生症 空腹胰岛素 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]