他汀类药物抗氧化与血红素氧化酶-1蛋白表达的关系  

Effects of statins and ACEI/ARB treatment on Heme Oxidase-1 expression

作　　者：张云[1] 许端敏[1] 陈宋明[1] 

机构地区：[1]汕头大学医学院第一附属医院心内科,515041

出　　处：《中国综合临床》2011年第1期86-88,共3页Clinical Medicine of China

摘　　要：目的 观察冠心病患者使用他汀类药物、血管紧张素转化酶抑制剂和血管紧张素受体拮抗剂等抗氧化剂治疗对血红素氧化酶-1表达水平的影响.方法 使用Western blot方法检测经冠状动脉造影确诊的60例冠心病患者抗氧化治疗后3个月外周血白细胞血红素氧化酶-1表达含量的变化.结果 治疗前血红素氧化酶-1表达水平是112.7±6.3（蛋白带灰度峰值）,抗氧化治疗后表达水平增至168.9±6.8,差异有统计学意义（t=2.432,P=0.008）.结论 他汀类药物、血管紧张素转化酶抑制剂和血管紧张素受体拮抗剂对冠心病的治疗作用可能是通过促进血红素氧化酶-1表达实现的.Objective To observe the effects of statins, angiotensin-converting enzyme inhibitor/adrenergic receptor binder （ ACEI/ARB ） treatment on Heme Oxidase-1 （ HO-1 ） expression in patients with coronary artery disease. Methods HO-1 expression in periphery white blood cells was detected using Western blot before and after 3 months treatment of the above antioxidants in 60 patients who were diagnosed as coronary artery disease by coronary angiography. Results HO-1 expression measured by gray scale peak by western blot was significantly higher after 3 months antioxidant treatment than that before antioxidant treatment（ 168. 9 t6. 8vs 112.7 ± 6.3, P = 0.008 ）. Conclusion Effects of statins and ACEI/ARB in treating coronary artery disease may be due to its promoting expression of HO-1.

关 键 词：冠心病 抗氧化治疗 血红素氧化酶-1 

分 类 号：R541.4[医药卫生—心血管疾病]