旋毛虫p53糖蛋白抗原研究进展  

Progress on p53 Glycoprotein Antigen of Trichinella

作　　者：王鸿盛[1,2] 付宝权[1] 

机构地区：[1]中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室农业部兽医公共卫生重点开放实验室甘肃省动物寄生虫病重点实验室,甘肃兰州730046 [2]甘肃农业大学动物医学院,甘肃兰州730070

出　　处：《动物医学进展》2011年第1期81-85,共5页Progress In Veterinary Medicine

基　　金：国家科技支撑计划项目(2007BAD40B03)

摘　　要：旋毛虫p53糖蛋白是旋毛虫肌幼虫排泄分泌抗原的主要抗原组分之一,具有肌幼虫期特异表达特性,主要定位在肌幼虫β-杆细胞。不同旋毛虫种p53糖蛋白氨基酸序列相对保守,但抗原性有差异,在同一种内变异极少,具有种及属特异性抗原表位。论文就旋毛虫p53糖蛋白抗原的分子结构、不同发育时期的特异性表达、抗原性等方面的研究进展进行综述。P53 glycoprotein is one of the major antigenic components of Trichinella muscle larva excretory secretory antigen and is mainly expressed in the β-stichocyte of muscle larvae.This protein is relatively conservative among different Trichinella species but shows antigenicty difference and rare intra-species variation was observed.Species-specific and genus-specific immunodominant epitopes on p53 glycoprotein were already defined.In this paper,the research progresses on molecular structure,specific expression in different developmental stages and the antigenicity of p53 glycoprotein antigen of Trichinella spp.were reviewed.

关 键 词：旋毛虫 p53糖蛋白 抗原 

分 类 号：S852.731[农业科学—基础兽医学]