妊高征孕妇血及其新生儿脐血5-羟色胺含量的测定及意义  

Determination of Plasma Serotonins Level in Patients with Pregnancy Induced Hypertension

作　　者：赵文霞[1,2] 赵莲茹[1,2] 赵文艳[1,2] 邢继强[1,2] 孙欣[1,2] 曹丽秋[1,2] 何凤兰[1,2] 明岩[1,2] 周建新[1,2] 

机构地区：[1]黑龙江省佳木斯市中心医院妇产科 [2]佳木斯市第二人民医院妇产科

出　　处：《中华妇产科杂志》1999年第7期406-408,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的探讨妊高征孕妇血及其新生儿脐血中５羟色胺（５ＨＴ）及代谢产物———５羟吲哚（５ＨＩＡＡ）的含量。方法用ＲＦ５０００型荧光分光光度计测定６０例妊高征患者（妊高征组），４０例正常晚孕妇女（对照组）的静脉血及两组各３８例新生儿脐血血浆中５ＨＴ、５ＨＩＡＡ及血小板中５ＨＴ含量。结果对照组母血中５ＨＴ为（５４．１６±１０．１３）ｎｍｏｌ／Ｌ，５ＨＩＡＡ为（４３．６２±６．３７）ｎｍｏｌ／Ｌ，新生儿脐血中５ＨＴ为（５０．２３±７．８３）ｎｍｏｌ／Ｌ，５ＨＩＡＡ为（４１．７３±８．６１）ｎｍｏｌ／Ｌ；妊高征组母血中５ＨＴ为（８６．２４±１４．３７）ｎｍｏｌ／Ｌ，５ＨＩＡＡ为（６２．３７±８．３４）ｎｍｏｌ／Ｌ，新生儿脐血中５ＨＴ为（７１．５６±１０．１３）ｎｍｏｌ／Ｌ，５ＨＩＡＡ为（６２．３７±１１．３７）ｎｍｏｌ／Ｌ。妊高征组与对照组比较，母血及新生儿脐血中５ＨＴ和５ＨＩＡＡ含量显著升高（Ｐ＜０．０１），且与疾病严重程度呈正相关。结论血浆５ＨＴ、５ＨＩＡＡ含量升高，可能与妊高征发病有关。Objective To determine whether levels of serotonin(5HT) and 5hydroxyindoleacetic acid (5HIAA) play an important role in the pathogenesis of pregnancy induced hypertension (PIH). Methods Maternal venous blood were collected from 60 women with PIH and 40 normotensive pregnant women in third trimester as control, and umbilical venous blood were collected from 38 newborns in each groups. Plasma and platelet 5HT and 5HIAA levels were measured by spectrophotometry. Results The mean 5HT level was (54.1610.13) nmol/L and 5HIAA was (43.626.37) nmol/L in maternal plasma, while they were (50.237.83) nmol/L and (41.738.61) nmol/L in umbilical plasma respectively in the normotensive group. The mean 5HT was (86.2414.37) nmol/L and 5HIAA was (62.378.34) nmol/L in maternal plasma of patients with PIH. While the mean 5HT was (71.5610.13) nmol/L and 5HIAA was (62.3711.37) nmol/L in umbilical plasma in PIH group. 5HT and 5HIAA levels in maternal and umbilical blood of PIH groups were significantly higher than that in the control group (P<0.01). ConclusionsBZThe markedly elevated plasma 5HT and 5HIAA levels might be caused by the increased release of 5HT by platelet. The result showed that elevated levels of 5HT and 5HIAA in patients with PIH might take part in the pathogenesis of PIH.

关 键 词：妊娠高血压 脐血 5-羟色胺 分光光度法 

分 类 号：R714.246[医药卫生—妇产科学]