2009年深圳市外来劳务工血清乙肝标志物与HBV-DNA的检测分析  

Analysis on the Detecting of HBV Serological Biomarkers and HBV DNA Among Migrant Workers in Shenzhen in 2009

作　　者：蔡春林[1] 张仁利[2] 姚相杰[2] 黄一燕[1] 

机构地区：[1]深圳市罗湖区疾病预防控制中心,广东深圳518020 [2]深圳市疾病预防控制中心

出　　处：《实用预防医学》2011年第1期47-49,共3页Practical Preventive Medicine

摘　　要：目的了解深圳市外来劳务工乙肝病毒的感染情况,探讨劳务工血清乙肝标志物与乙肝DNA之间的关系。方法利用ELISA法对235份深圳市外来劳务工的血清标本进行乙肝五项检测,并应用实时荧光定量PCR法检测乙肝患者的HBV-DNA水平。结果在235例感染乙肝病毒的外来劳务工中,30岁以下劳务工患者占总的乙肝病毒感染人数的74.89%。大三阳(1,3,5阳性)和小三阳(1,4,5阳性)患者占劳务工乙肝患者总数的77.45%,其乙肝DNA的检出率分别为97.8%和68.8%,HBsAg(+)和HBcAb(+)患者的HBV-DNA的阳性率为76.5%。结论乙肝五项不足以真实反映乙肝患者的病毒复制水平,对于年青外来劳务工乙肝五项异常者必须进行DNA测定以正确判断患者的传染性,从而为乙肝的防控和治疗提供依据。Objective To understand the epidemiological statue of HBV infection and to explore the relationship between the HBV serological biomarkers and HBV DNA among migrant workers in Shenzhen Methods ELISA and Real-time PCR were used to detect 235 migrant workers HBV serological biomarkers and HBV-DNA Results Migrant workers with age below 30 account for 74.89% of the 235 hepatitis B patients.Group A {HBsAg（＋）HBeAg（＋）HBcAb（＋）} and B {HBsAg（＋）HBeAb（＋）HBcAb（＋） } patients account for 77.45% of the total hepatitis B patients.Serum HBV-DNA detection rate of group A,B and C{ HBsAg（＋） and HBcAb（＋）}were 97.8%,68.8% and 76.5%,respectively. Conclusions HBV serological biomarkers are not enough to illustrate the replication status of HBV virus.It is necessary to detect HBV DNA for younge migrant workers with hepatitis B virus infection so as to determine the infectivity correctly and provide basis for the prevention and treatment of hepatitis B.

关 键 词：劳务工 乙肝 血清 DNA 

分 类 号：R373.21[医药卫生—病原生物学]