32种藏药提取物抗单纯疱疹Ⅰ型病毒的活性筛选  

Investigation on anti-herpes simplex virus type I effect of extracts from 32 kinds of Tibetan medicinal herbs

作　　者：吉守祥[1] 周建青[2] 李深[3] 向阳飞[3] 鞠怀强[3] 王一飞[3] 

机构地区：[1]青海民族大学化学与生命科学学院,青海西宁810007 [2]青海师范大学化学系,青海西宁810008 [3]暨南大学生物医药研究开发基地,广东广州510632

出　　处：《华西药学杂志》2011年第1期30-31,共2页West China Journal of Pharmaceutical Sciences

基　　金：青海省科技厅科技成果推广项目(No.2008-J-528);国家自然科学基金广东省人民政府自然科学联合基金(No.U0632010)

摘　　要：目的从32种藏药提取物中筛选具有抗单纯疱疹病毒Ⅰ型(HSV-Ⅰ)活性的成分。方法采用细胞病变效应法测定不同藏药提取物的细胞毒性及抗HSV-I活性。结果从32种藏药提取物中找到了2种含有抗单纯疱疹病毒Ⅰ型的活性成分,即甘青青兰和蓝花荆芥。结论进一步研究两种提取物及其相关化合物,有望开发出新的抗单纯疱疹I型病毒的新药。OBJECTIVE To screen the active extracts with anti-herpes simplex virus type I activity from 32 kinds of Tibetan medicinal herbs.METHODS Cytopathogenic effect was adopted to measure cytotoxicity and anti-HSV-I activity of different extracts.RESULTS Two active extracts from 32 Tibetan medicinal herbs were found to have anti-herpes simplex virus type Ⅰ activity.CONCLUSION The further research on two extracts and relevant compounds would be continued.It＇s hopefully to developed a new drug with anti-herpes simplex virus type I.

关 键 词：藏药 单纯疱疹病毒I型 细胞病变效应法 活性 

分 类 号：R93[医药卫生—生药学] R96[医药卫生—药学]