慈竹提取物对大鼠急性心肌缺血的影响  

Effects of Sinocalamus affinis extracts on the acute myocardial ischemia of rats

作　　者：郭英[1,2] 谢建平 沈志强[4] 莫正纪[2] 

机构地区：[1]昆明医学院基础医学院,云南昆明650500 [2]四川大学华西药学院,四川成都610041 [3]云南省药物研究所,云南昆明650111 [4]昆明医学院云南省天然药物药理重点实验室,云南昆明650500

出　　处：《华西药学杂志》2011年第1期39-40,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的研究慈竹提取物对大鼠急性心肌缺血的影响。方法采用离体心脏灌流法、垂体后叶素致心肌缺血及结扎冠状动脉致心肌缺血的方法。结果慈竹提取物可使大鼠离体心脏灌流量增加、心率减慢、心肌收缩力减弱,减少垂体后叶素所致心肌缺血的发生率,减少结扎冠状动脉所致心电图J点的偏移。结论慈竹提取物对大鼠急性心肌缺血的心脏有保护作用。OBJECTIVE To investigate the effects of Sinocalamus affinis extracts on the acute myocardial ischemia of rats.METHODS Langendorff-perfusion isolated rat hearts was employed.Acute myocardial ischemia was induced by pituitrin and ligating coronary artery.RESULTS Sinocalamus affinis extracts increased coronary artery flow,decreased heart rate and tension of heart in vitro contrarily.It decreased positive rate of myocardial ischemia caused by pituitrin,and drift of point J caused by ligating coronary artery.CONCLUSION Sinocalamus affinis extracts could recover acute myocardial ischemia of rats.

关 键 词：慈竹提取物 离体心脏 垂体后叶素 心肌缺血 

分 类 号：R96[医药卫生—药理学]