电压依赖性钾离子通道在肺动脉高压发病过程中的作用  

Role of voltage-gated potassium channels in the pathogenesis of pulmonary artery hypertension

作　　者：李晶[1] 王军[1] 

机构地区：[1]首都医科大学生理学教研室,北京100069

出　　处：《国际呼吸杂志》2011年第3期238-240,共3页International Journal of Respiration

基　　金：国家自然科学基金（81070042）;国家重点基础研究发展计划（2009CB522107）;国家自然科学基金国际（地区）合作与交流（30810103901）：教育部科学技术研究重点项目（208002）;北京市自然科学基金（7082012）;北京市教育委员会科技发展计划（KM200710025002）

摘　　要：肺动脉高压是一种肺血流受限引起肺血管阻力和压力持续性增高，最终导致右心衰竭甚至死亡的综合征。病理生理学改变主要为肺血管收缩、重塑及原位血栓形成。研究表明，钾离子通道尤其电压依赖性钾离子通道功能与表达水平的降低是引起肺血管平滑肌细胞增殖和凋亡异常、肺血管重塑的关键因素。本文着重论述近年来有关电压依赖性钾离子通道与肺动脉高压肺血管重塑发生相关机制的研究进展。Pulmonary artery hypertension （PAH） is a syndrome induced by restricted flow of pulmonary artery, which leads to sustainable increases in pulmonary vascular resistance and pulmonary artery pressure and even right heart failure. The predominant pathogenic mechanisms of PAH are pulmonary vasoconstriction, vascular remodeling and in situ thrombus formation. Researches show that down regulation of potassium channels especially voltage-gated potassium channels （Kv） is associated with the imbalance between proliferation and apoptosis in pulmonary artery smooth muscle cells, which in turn to pulmonary vascular remodeling. This review concentrates on the effect of Kv channels in leading to pulmonary artery remodeling in human PAH and its possible mechanism.

关 键 词：电压依赖性钾离子通道 肺血管平滑肌细胞 细胞增殖和凋亡 肺血管重塑 肺动脉高压 

分 类 号：R543.2[医药卫生—心血管疾病]